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Decoding the microbiota metabolome in hepatobiliary and pancreatic cancers: Pathways to precision diagnostics and targeted therapeutics.
Xu, Yuemiao; Le, Jiahan; Qin, Jiangjiang; Zhang, Yuhua; Yang, Jiaying; Chen, Zhuo; Li, Changyu; Qian, Xiang; Zhang, Aiqin.
Afiliación
  • Xu Y; Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • Le J; Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • Qin J; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310000, China.
  • Zhang Y; Zhejiang Cancer Hospital, Hangzhou 310022, China.
  • Yang J; Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • Chen Z; Zhejiang Cancer Hospital, Hangzhou 310022, China.
  • Li C; Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • Qian X; Zhejiang Cancer Hospital, Hangzhou 310022, China. Electronic address: qianxiang@zjcc.org.cn.
  • Zhang A; Zhejiang Cancer Hospital, Hangzhou 310022, China. Electronic address: zhangaq@zjcc.org.cn.
Pharmacol Res ; 208: 107364, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39181345
ABSTRACT
We delve into the critical role of the gut microbiota and its metabolites in the pathogenesis and progression of hepatobiliary and pancreatic (HBP) cancers, illuminating an urgent need for breakthroughs in diagnostic and therapeutic strategies. Given the high mortality rates associated with HBP cancers, which are attributed to aggressive recurrence, metastasis, and poor responses to chemotherapy, exploring microbiome research presents a promising frontier. This research highlights how microbial metabolites, including secondary bile acids, short-chain fatty acids, and lipopolysaccharides, crucially influence cancer cell behaviors such as proliferation, apoptosis, and immune evasion, significantly contributing to the oncogenesis and progression of HBP cancers. By integrating the latest findings, we discuss the association of microbial alterations with HBP cancers, key metabolites, and their implications, and how metabolomics and microbiomics can enhance diagnostic precision. Furthermore, the paper explores strategies for targeted therapies through microbiome metabolomics, including the direct therapeutic effects of microbiome metabolites and potential synergistic effects on conventional therapies. We also recognize that the field of microbial metabolites for the diagnosis and treatment of tumors still has a lot of problems to be solved. The aim of this study is to pioneer microbial metabolite research and provide a reference for HBP cancer diagnosis, treatment, and prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Metaboloma / Microbioma Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Metaboloma / Microbioma Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos