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A novel glycopeptide from mountain-cultivated ginseng residue protects type 2 diabetic symptoms-induced heart failure.
Li, Zhuoran; Zhou, Dongyue; Wu, Tongchuan; Lee, Hyogeun; Zheng, Fei; Dai, Yulin; Yue, Hao.
Afiliación
  • Li Z; Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address: lizr@ccucm.edu.cn.
  • Zhou D; Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address: 2889248207@qq.com.
  • Wu T; Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address: 1294458419@qq.com.
  • Lee H; Jeju National University, Jeju 63243, Republic of Korea. Electronic address: hyogeunlee92@gmail.com.
  • Zheng F; Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address: zhengfei@ccucm.edu.cn.
  • Dai Y; Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address: daiyl@ccucm.edu.cn.
  • Yue H; Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address: yuehao@ccucm.edu.cn.
J Ethnopharmacol ; 336: 118723, 2025 Jan 10.
Article en En | MEDLINE | ID: mdl-39181285
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Mountain-cultivated Panax ginseng C.A.Mey. (MCG) with high market price and various properties was valuable special local product in Northeast of Asia. MCG has been historically used to mitigate heart failure (HF) for thousand years, HF is a clinical manifestation of deficiency of "heart-qi" in traditional Chinese medicine. However, there was little report focus on the activities of extracted residue of MCG. AIM OF THE STUDY A novel glycopeptide (APMCG-1) was isolated from step ethanol precipitations of alkaline protease-assisted extract from MCG residue. MATERIALS AND

METHODS:

The molecular weight and subunit structure of APMCG-1 were determined by FT-IR, HPLC and GPC technologies, as well as the H9c2 cells, Tg (kdrlEGFP) zebrafish were performed to evaluated the protective effect of APMCG-1.

RESULTS:

APMCG-1 was identified as a glycopeptide containing seven monosaccharides and seven amino acids via O-lined bonds. Further, in vitro, APMCG-1 significantly decreased reactive oxygen species production and lactate dehydrogenase contents in palmitic acid (PA)-induced H9c2 cells. APMCG-1 also attenuated endoplasmic reticulum stress and mitochondria-mediated apoptosis in H9c2 cells via the PI3K/AKT signaling pathway. More importantly, APMCG-1 reduced the blood glucose, lipid contents, the levels of heart injury, oxidative stress and inflammation of 5 days post fertilization Tg (kdrlEGFP) zebrafish with type 2 diabetic symptoms in vivo.

CONCLUSIONS:

APMCG-1 protects PA-induced H9c2 cells while reducing cardiac dysfunction in zebrafish with type 2 diabetic symptoms. The present study provides a new insight into the development of natural glycopeptides as heart-related drug therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Glicopéptidos / Diabetes Mellitus Tipo 2 / Panax / Insuficiencia Cardíaca Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2025 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Glicopéptidos / Diabetes Mellitus Tipo 2 / Panax / Insuficiencia Cardíaca Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2025 Tipo del documento: Article Pais de publicación: Irlanda