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Rising incidence of obesity-related cancers among younger adults in China: A population-based analysis (2007-2021).
Liu, Chang; Yuan, Ying-Chao; Guo, Mo-Ning; Xin, Zhong; Chen, Guan-Jie; Ding, Nan; Zheng, Jian-Peng; Zang, Bai; Yang, Jin-Kui.
Afiliación
  • Liu C; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
  • Yuan YC; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
  • Guo MN; Beijing Municipal Health Big Data and Policy Research Center, Beijing 100034, China.
  • Xin Z; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
  • Chen GJ; The Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ding N; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.
  • Zheng JP; Beijing Municipal Health Big Data and Policy Research Center, Beijing 100034, China.
  • Zang B; Beijing Municipal Health Big Data and Policy Research Center, Beijing 100034, China.
  • Yang JK; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China. Elec
Med ; 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-39181132
ABSTRACT

BACKGROUND:

Developing countries face an "obesity epidemic," particularly affecting children and younger adults. While obesity is a known risk factor for 12 types of cancer, primarily affecting older populations, its impact on younger generations is understudied.

METHODS:

This study analyzed data from a population-based cancer registry covering 14.14 million individuals in China (2007-2021). We compared the incidence of obesity- and non-obesity-related cancers and applied an age-period-cohort model to estimate their impacts.

FINDINGS:

Among 651,342 cancer cases, 48.47% were obesity related. The age-standardized incidence rates (ASRs) of the 12 obesity-related cancers increased annually by 3.6% (p < 0.001), while ASRs for non-obesity-related cancers remained stable. Obesity-related cancers surged among younger adults, with rates rising across successive generations. The annual percentage of change decreased with age, from 15.28% for ages 25-29 years to 1.55% for ages 60-64 years. The incidence rate ratio for obesity-related cancer was higher in younger generations compared to those born in 1962-1966. We predict that the ASR for obesity-related cancers will nearly double in the next decade.

CONCLUSIONS:

The rising incidence of obesity-related cancers among young adults poses a significant public health concern. The increasing cancer burden underscores the need for targeted interventions to address the obesity epidemic.

FUNDING:

This work was supported by the National Natural Science Foundation of China (81930019, 82341076) to J.-K.Y.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos