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Exploring mean platelet volume and neutrophil-to-albumin ratio as surrogate markers for monitoring tuberculosis treatment: a prospective longitudinal study.
Rajakumar, Hamrish Kumar; Coimbatore Sathyabal, Varsha; Palaniyandi, Arulkumaran; Balakrishnan, Dakshinamurthy.
Afiliación
  • Rajakumar HK; Government Medical College, Omandurar Government Estate, Chennai, India. hamrishkumar2003@gmail.com.
  • Coimbatore Sathyabal V; Government Medical College, Omandurar Government Estate, Chennai, India.
  • Palaniyandi A; Department of Respiratory Medicine, Government Medical College, Omandurar Government Estate, Chennai, India.
  • Balakrishnan D; Department of Respiratory Medicine, Government Medical College, Omandurar Government Estate, Chennai, India.
BMC Pulm Med ; 24(1): 406, 2024 Aug 23.
Article en En | MEDLINE | ID: mdl-39180021
ABSTRACT

BACKGROUND:

Tuberculosis (TB) remains a global health challenge, with India bearing a significant burden. Despite advancements in TB diagnosis and treatment, monitoring TB treatment is challenging, particularly in resource-limited settings. This study aimed to explore the mean platelet volume (MPV) as a potential surrogate marker for monitoring TB treatment and assessing if the neutrophil-to-albumin ratio (NAR) enhances treatment monitoring.

METHODS:

Patients diagnosed with TB following NTEP guidelines were recruited. Participants underwent routine blood tests during the six-month Anti-Tubercular therapy course at the start, end of the intensive phase, and end of the continuous phase. Statistical analyses included Spearman correlation, Friedman test, linear mixed effects (LME) models, and multiple linear regression.

RESULTS:

150 individuals were included for analysis. Deviations from normality were noted. Significant associations were found between CRP and sputum grade. MPV mediated between CRP and sputum grade. Significant differences were observed across the three-time points. LME models showed changes in MPV and CRP levels over time. Including NAR enhanced predictive capability.

CONCLUSIONS:

MPV may serve as a promising surrogate marker for monitoring ATT. Personalized approaches are crucial in TB treatment monitoring. LME models revealed MPV and CRP level trends. Future research should explore MPV's treatment response mechanisms and cost-effectiveness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Volúmen Plaquetario Medio / Neutrófilos / Antituberculosos Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Pulm Med Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Volúmen Plaquetario Medio / Neutrófilos / Antituberculosos Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Pulm Med Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido