Your browser doesn't support javascript.
loading
High-intensity interval training improves cardiovascular and physical health in patients with rheumatoid arthritis: a multicentre randomised controlled trial.
Bilberg, Annelie; Mannerkorpi, Kaisa; Borjesson, Mats; Svedlund, Sara; Sivertsson, Jenny; Klingberg, Eva; Bjersing, Jan.
Afiliación
  • Bilberg A; Institute of Neuroscience and Physiology, Department of Health and Rehabilitation, Physiotherapy, University of Gothenburg Sahlgrenska Academy, Goteborg, Sweden annelie.bilberg@vgregion.se.
  • Mannerkorpi K; Department of Occupational and Physiotherapy, Sahlgrenska University Hospital, Goteborg, Sweden.
  • Borjesson M; Institute of Neuroscience and Physiology, Department of Health and Rehabilitation, Physiotherapy, University of Gothenburg Sahlgrenska Academy, Goteborg, Sweden.
  • Svedlund S; Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Goteborg, Sweden.
  • Sivertsson J; Center for Lifestyle Intervention, Department of MGAÖ, Sahlgrenska University Hospital, Goteborg, Sweden.
  • Klingberg E; Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg Sahlgrenska Academy, Goteborg, Sweden.
  • Bjersing J; Department of Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden.
Br J Sports Med ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39179363
ABSTRACT

OBJECTIVES:

Patients with rheumatoid arthritis (RA) have substantially elevated risk for cardiovascular diseases, and low cardiorespiratory fitness (VO2max) is a major mediator. The aim of this assessor-blinded, two-armed multicentre randomised controlled trial was to evaluate the effects of high-intensity interval training (HIIT) and strength exercise on cardiovascular health, physical fitness and overall health in patients with RA.

METHODS:

In total, 87 patients (86% female; aged 20-60 years) were randomly assigned to an intervention group (IG) or a control group (CG). The IG performed HIIT and strength exercise for 12 weeks. The CG was instructed to be physically active on a moderately intensive level, ≥150 min/week. Primary outcome was change in VO2max. Secondary outcomes were changes in anthropometry measures, muscle strength, overall health (Visual Analogue Scale (VAS)-Global), Patient Global Impression of Change (PGIC), pain and disease activity (Disease Activity Score in 28 joints (DAS28)).

RESULTS:

There was a significant mean group difference of change on VO2max (3.71 mL/kg/min; 95% CI 2.16, 5.25) in favour of the IG. Significant mean group differences of change were also seen for O2-pulse (1.38; 95% CI 0.85 to 1.91), waist circumference (-2.6; 95% CI -5.09 to -0.18), 1-minute sit-to-stand (5.0; 95% CI 3.35 to 6.72), handgrip strength (28.5; 95% CI 3.80 to 52.8), overall health (-14.7; 95% CI -23.8 to -5.50) and PGIC (p<0.0001) in favour of the IG. No significant mean group differences of change were found for pain (-4.0; 95% CI -13.07 to 5.06), DAS28 (-0.25; 95% CI -0.60 to 0.10) and erythrocyte sedimentation rate (-0.64; 95% CI -3.23 to 1.90).

CONCLUSION:

Supervised HIIT and strength exercise improved cardiovascular health, physical fitness and overall health without a deterioration in pain and disease activity and should be considered in patients with well-controlled RA. TRIAL REGISTRATION NUMBER NCT05768165.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Br J Sports Med Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Br J Sports Med Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido