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Comparison of Clinical Outcomes in the Slow-Developing Blastocysts With or Without Preimplantation Genetic Testing-Aneuploidy on Day 6 in the Frozen-Thawed Cycle.
Lee, Hee Jun; Park, Jae Eun; Jeong, Jihye; Kim, Tae Hyung; Yoon, Sola; Han, Jisoo; Eum, Jin Hee; Sung, Hyelim; Choi, Youngsok; Lee, Woo Sik.
Afiliación
  • Lee HJ; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea. Electronic address: alonfo@chamc.co.kr.
  • Park JE; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Jeong J; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Kim TH; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Yoon S; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Han J; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Eum JH; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Sung H; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
  • Choi Y; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 450-3517, Korea.
  • Lee WS; Fertility Center of CHA Gangnam Medical Center, CHA University of Medicine, Seoul 3468-3169, Korea.
J Obstet Gynaecol Can ; : 102644, 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39179155
ABSTRACT

OBJECTIVE:

This study investigated the potential of the slow-developing blastocysts using preimplantation genetic testing-aneuploidy (PGT-A) in patients undergoing frozen-thawed embryo transfer, stratified by age. STUDY

DESIGN:

A retrospective analysis was performed including a total of 743, the first frozen embryo transfer (FET) cycle with single embryo transfer (SET), who underwent treatment between January 2020 and July 2023 in a single fertility center, XXXX Fertility Center. A total of 743 cycles, in which we performed intracellular sperm injection and freeze all strategy, from 743 patients were included. The patient group was divided into 4 groups as follows Group 1 (G1), 208 FET on day 5; Group 2 (G2), 177 FET with PGT-A on day 5; Group 3 (G3), 220 FET on day 6; Group 4 (G4), 138 FET with PGT-A on day 6. We also divided into two groups-under 35 years of age and over 35 years of age-and performed the analysis separately for each group.

RESULTS:

In under 35 years of age groups, there were no significant differences in clinical pregnancy and miscarriage rates in G1 and G2 (67.2% vs 63.8%, NS). Also, G4 had a higher clinical pregnancy rate than G3, but it was not significant (51.8% vs 54.7%, NS). In 35 years or older group, G2 had higher pregnancy rates than G1 and lower miscarriage rates (CPR 43.3% vs 67.7%, P = 0.001, MR 22.5% vs 3.4%, P = 0.001). In addition, G4 had a higher pregnancy rate than G3 and lower miscarriage rate (CPR 31.8% vs. 46.9%, P = 0.003, MR 22.9% vs 2.2%, P = 0.023).

CONCLUSIONS:

In ≥35 years group, PGT-A on day 5 and day 6 showed a high pregnancy rate and a low miscarriage rate. Therefore, using PGT-A seems advantageous for patients of an advanced maternal age.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Obstet Gynaecol Can Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Obstet Gynaecol Can Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos