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Modified frankincense resin stabilized gold nanoparticles for enhanced antioxidant and synergetic activity in in-vitro anticancer studies.
Seku, Kondaiah; Bhagavanth Reddy, G; Osman, Ahmed I; Hussaini, Syed Sulaiman; Kumar, Nadavala Siva; Al-Abri, Mohammed; Pejjai, Babu; Alreshaidan, Salwa B; Al-Fatesh, Ahmed S; Kadimpati, Kishore Kumar.
Afiliación
  • Seku K; Department of Engineering, College of Engineering and Technology, University of Technology and Applied Sciences -, Shinas, Sultanate of Oman. Electronic address: kondaiah.seku@utas.edu.om.
  • Bhagavanth Reddy G; Department of Chemistry, Palamuru University PG Center, Wanaparthy, Telangana State, India.
  • Osman AI; School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, United Kingdom of Great Britain and Northern Ireland. Electronic address: aosmanahmed01@qub.ac.uk.
  • Hussaini SS; Department of Engineering, College of Engineering and Technology, University of Technology and Applied Sciences -, Shinas, Sultanate of Oman.
  • Kumar NS; Department of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia.
  • Al-Abri M; Nanotechnology Research Center, Sultan Qaboos University, Muscat, Oman; Department of Petroleum and Chemical Engineering, College of Engineering, Sultan Qaboos University, Muscat, Oman.
  • Pejjai B; Department of Physics, Sri Venkateshwara College of Engineering, Karakambadi Road, Tirupati 517507, India.
  • Alreshaidan SB; Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 800, Riyadh 11451, Saudi Arabia.
  • Al-Fatesh AS; Department of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia.
  • Kadimpati KK; Department of Environmental Biotechnology, Faculty of Power and Environmental Engineering, Akademicka 2, Silesian University of Technology, 44 - 100 Gliwice, Poland. Electronic address: kishore.kumar.kadimpati@polsl.pl.
Int J Biol Macromol ; 278(Pt 3): 134935, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39179088
ABSTRACT
For the first time, Frankincense resin (FR) has been carboxymethylated to produce CMFR - AuNPs and the conjugate was utilized for the Doxorubicin drug loading. The carboxymethylation of the carboxylic, phenolic, and hydroxyl functional groups of FR has been developed into carboxymethylated Frankincense resin (CMFR). A novel CMFR-AuNPs was synthesized using the developed CMFR as a stabilizing and reducing agent. The antibacterial, antioxidant, and in-vitro anticancer activities were investigated by using CMFR-AuNPs and CMFR - AuNPs@DOX. CMFR-AuNPs demonstrated antioxidative properties by quenching DPPH radicals effectively. CMFR-AuNPs and DOX@CMFR-AuNPs demonstrated strong antibacterial activity against K. pneumoniae, S. aureus, B. subtilis, and E. coli. The cell viability was tested for CMFR -AuNPs at various concentrations of Dox-loaded CMFR -AuNPs (CMFR-AuNPs + Dox1, CMFR-AuNPs + Dox 2, & CMFR-AuNPs + Dox 3). The highest inhibition was observed on MCF-7 and HeLa cell lines using CMFR-AuNPs + Dox 3, respectively. Various techniques such as UV, FTIR, TGA, XRD, SEM, EDAX and TEM were used to characterize the designed CMFR and CMFR-AuNPs. After carboxy methylation, the amorphous nature of FR changed to crystallinity, as reflected in the XRD spectra. The XRD spectrum of the CMFR- AuNPs showed FCC structure due to the involvement of hydroxyl and carboxylic functional groups of CMFR strongly bound with the AuNPs. TGA results revealed that the CMFR is thermally more stable than FR. TEM revealed that CMFR - AuNPs were well dispersed, spherical, and hexagonal with an average diameter of 7 to 10 nm, while the size of doxorubicin loaded (DOX@CMFR-AuNPs) AuNPs was 11 to 13 nm. Green CMFR-AuNPs have the potential to enhance the drug loading and anticancer efficacy of drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Nanopartículas del Metal / Oro / Antineoplásicos / Antioxidantes Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Nanopartículas del Metal / Oro / Antineoplásicos / Antioxidantes Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos