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Prevalence and etiotypes of persistent airflow obstruction in the general population across the lifetime.
Grasl, M T; Agusti, A; Azizzadeh, M; Karimi, A; Hartl, S; Breyer, M-K; Breyer-Kohansal, R.
Afiliación
  • Grasl MT; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Department of Respiratory and Pulmonary Diseases, Clinic Penzing, Vienna Healthcare Group, Vienna, Austria. Electronic address: marie-therese.grasl@leadstudy.at.
  • Agusti A; Cátedra de Salud Respiratoria, University of Barcelona, Respiratory Institute Clinic Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomedica en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
  • Azizzadeh M; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Sigmund Freud Private University, Faculty of Medicine, Vienna, Austria.
  • Karimi A; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Sigmund Freud Private University, Faculty of Medicine, Vienna, Austria.
  • Hartl S; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Sigmund Freud Private University, Faculty of Medicine, Vienna, Austria.
  • Breyer MK; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Department of Respiratory and Pulmonary Diseases, Clinic Penzing, Vienna Healthcare Group, Vienna, Austria.
  • Breyer-Kohansal R; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Department of Respiratory and Pulmonary Diseases, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria.
Respir Med ; 233: 107779, 2024 11.
Article en En | MEDLINE | ID: mdl-39179051
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Different factors (etiotypes) can lead to persistent airflow obstruction (PAO) across the lifetime, including genetic factors, abnormal lung development, cigarette smoking, traffic pollution exposure, respiratory infections and asthma. Here we explore the prevalence of PAO and associated etiotypes in the general population in different age bins.

METHODS:

We studied 664 individuals with PAO (FEV1/FVC post bronchodilation (post-BD) below the lower limit of normal (LLN)) and 11,522 with normal lung function (FEV1/FVC, FEV1 and FVC ≥ LLN and ≤ upper limit of normal (ULN) post-BD) included in the LEAD Study (NCT01727518), a general population cohort in Vienna (Austria). For analysis, participants were stratified in three age bins (<25, 25-<50 and ≥ 50 years of age).

RESULTS:

PAO occurred in 3.8 % in females and 5.6 % in males of the cohort, and it increased with age. Most participants with PAO (57.5 %) reported respiratory symptoms, indicating a high burden of disease. PAO was associated with male sex (25-<50 years), ever smoking (>50 years), increased number of pack years (25-<50 years, >50 years), not being breastfed (<25 years) and ever diagnosis of asthma (in all age bins). Etiotypes varied by age bins with cigarette smoking being the most prevalent one, often in combination with traffic pollution exposure.

CONCLUSION:

In the general population PAO occurs in about 5 % of participants with a higher prevalence in older individuals. Etiotypes and associated factors for PAO accumulate with age.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Respir Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Respir Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido