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A comparative study on the haemostatic changes in kidney failure patients: Pre- and post- haemodialysis and haemodiafiltration.
Jessica, Caruana; Kevin, Vella; Marie, Vella Amy; Marica, Borg; Maria, Cini Masini; Emanuel, Farrugia; Liberato, Camilleri; Nicoletta, Riva; Alexander, Gatt.
Afiliación
  • Jessica C; Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida, Malta. Electronic address: Jessica.caruana.1@gov.mt.
  • Kevin V; Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. Electronic address: Kevin.c.vella@gov.mt.
  • Marie VA; Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. Electronic address: amy-marie.vella@gov.mt.
  • Marica B; Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. Electronic address: marica.a.borg@gov.mt.
  • Maria CM; Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta. Electronic address: maria.masini@gov.mt.
  • Emanuel F; Department of Nephrology, Mater Dei Hospital, Msida, Malta. Electronic address: Emanuel.farrugia@gov.mt.
  • Liberato C; Department of Statistics and Operations Research, Faculty of Science, University of Malta, Msida, Malta. Electronic address: liberato.camilleri@um.edu.mt.
  • Nicoletta R; Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: Nicoletta.riva@um.edu.mt.
  • Alexander G; Coagulation Medicine Laboratory, Department of Pathology, Mater Dei Hospital, Msida, Malta; Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta. Electronic address: alexander.a.gatt@gov.mt.
Thromb Res ; 242: 109120, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39178654
ABSTRACT

BACKGROUND:

Individuals with kidney failure have a compromised haemostatic system making them susceptible to both thrombosis and bleeding.

OBJECTIVES:

Assessment of primary haemostasis in patients treated with either haemodialysis (HD) or haemodiafiltration (HDF) was performed through the measurement of several coagulation-based tests, both pre- and post-dialysis. PATIENTS/

METHODS:

41 renal failure patients and 40 controls were recruited. Platelet aggregometry, Factor XIII (FXIII), Fibrinogen, Von Willebrand Factor (VWF) and Soluble P-Selectin (sP-Sel) levels were measured.

RESULTS:

Maximum platelet aggregation was diminished in renal patients irrespective of aspirin intake. Post-dialysis, platelet function was exacerbated. Pre-dialysis FXIII levels were similar to the healthy cohort and became elevated post-dialysis. This elevation could not be explained by the relative decrease of water by dialysis. Fibrinogen levels were already elevated pre-dialysis and further increased post-dialysis. This elevation was associated with the relative decrease of water by dialysis. VWF levels in males were similar to the healthy cohort and became elevated post-dialysis. This elevation was associated with dialysis-related water loss. VWF antigen and activity in female patients were already elevated pre-dialysis and further increased post-dialysis with the exception of VWF activity in HDF treated female patients. sP-Sel levels were lower than those of the healthy cohort and became similar to the healthy cohort post-dialysis. This elevation could not be explained by the relative decrease of water by dialysis.

CONCLUSIONS:

Whilst platelet aggregometry was diminished, we noted elevated clotting factors such as fibrinogen, FXIII and VWF with no significant differences between HD and HDF-treated patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Hemodiafiltración / Hemostasis Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Thromb Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Hemodiafiltración / Hemostasis Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Thromb Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos