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In vivo pharmacokinetics of ginsenoside compound K mediated by gut microbiota.
Deng, Ming-Si; Huang, Su-Tian-Zi; Xu, Ya-Ni; Shao, Li; Wang, Zheng-Guang; Chen, Liang-Jian; Huang, Wei-Hua.
Afiliación
  • Deng MS; Department of Stomatology, the Third Xiangya Hospital of Central South University, Central South University, Changsha, China.
  • Huang ST; Department of Orthodontics, Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Xu YN; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
  • Shao L; Department of Orthodontics, Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Wang ZG; Department of Pharmacognosy, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Chen LJ; Department of Spinal Surgery, the Third Xiangya Hospital of Central South University, Central South University, Changsha, China.
  • Huang WH; Department of Stomatology, the Third Xiangya Hospital of Central South University, Central South University, Changsha, China.
PLoS One ; 19(8): e0307286, 2024.
Article en En | MEDLINE | ID: mdl-39178246
ABSTRACT
Ginsenoside Compound K (GCK) is the main metabolite of natural protopanaxadiol ginsenosides with diverse pharmacological effects. Gut microbiota contributes to the biotransformation of GCK, while the effect of gut microbiota on the pharmacokinetics of GCK in vivo remains unclear. To illustrate the role of gut microbiota in GCK metabolism in vivo, a systematic investigation of the pharmacokinetics of GCK in specific pathogen free (SPF) and pseudo-germ-free (pseudo-GF) rats were conducted. Pseudo-GF rats were treated with non-absorbable antibiotics. Liquid chromatography tandem mass spectrometry (LC-MS/MS) was validated for the quantification of GCK in rat plasma. Compared with SPF rats, the plasma concentration of GCK significantly increased after the gut microbiota depleted. The results showed that GCK absorption slowed down, Tmax delayed by 3.5 h, AUC0-11 increased by 1.3 times, CLz/F decreased by 0.6 times in pseudo-GF rats, and Cmax was 1.6 times higher than that of normal rats. The data indicated that gut microbiota played an important role in the pharmacokinetics of GCK in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ginsenósidos / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ginsenósidos / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos