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A value hierarchy for inclusive design of heart valve implants in regenerative medicine.
De Kanter, Anne Johanna; Daal, Manon Van; Gunn, Callum J; Bredenoord, Annelien L; Graeff, Nienke De; Jongsma, Karin R.
Afiliación
  • De Kanter AJ; Department of Bioethics & Health Humanities, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, 3508 GA, The Netherlands.
  • Daal MV; Department of Bioethics & Health Humanities, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, 3508 GA, The Netherlands.
  • Gunn CJ; Department of Bioethics & Health Humanities, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, 3508 GA, The Netherlands.
  • Bredenoord AL; Erasmus School of Philosophy, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.
  • Graeff N; Department of Medical Ethics & Health Law, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.
  • Jongsma KR; Department of Bioethics & Health Humanities, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, 3508 GA, The Netherlands.
Regen Med ; 19(6): 289-301, 2024 06 02.
Article en En | MEDLINE | ID: mdl-39177570
ABSTRACT

Aim:

This paper investigates the conditions for inclusive design of regenerative medicine interventions from a bioethical perspective, taking regenerative valve implants as a showcase.

Methods:

A value hierarchy is construed to translate the value of justice into norms and design requirements for inclusive design of regenerative valve implants.

Results:

Three norms are proposed and translated into design requirements regenerative valve implants should be designed to promote equal opportunity to good health for all potential users; equal respect for all potential users should be shown; and the implants should be designed to be accessible to everyone in need.

Conclusion:

The norms and design requirements help to design regenerative valve implants that are appropriate, respectful and available for everyone in need.
Scientists in the field of regenerative medicine are developing a new type of heart valve implant. After implantation, the synthetic implant slowly breaks down and is replaced by a new living heart valve. These so-called regenerative implants promise a complete cure. However, they also raise ethical questions. For example, questions related to justice and inclusion. In this paper, we explore how regenerative implants can be designed to be inclusive, meaning suitable, respectful and available for everyone. We argue that the design of regenerative implants should be adapted to relevant differences between users. The implants should be affordable in the short and long term. The implants should be suitable for use worldwide. The implants should be designed by teams of diverse age, gender and ethnicity. Users should be engaged in the design. And the communication about the implants to researchers and users should be inclusive. Overall, this paper provides ethical guidance to researchers and clinicians developing regenerative implants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Valvulares Cardíacas / Medicina Regenerativa Límite: Humans Idioma: En Revista: Regen Med Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Valvulares Cardíacas / Medicina Regenerativa Límite: Humans Idioma: En Revista: Regen Med Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido