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How Can Spatial Transcriptomic Profiling Advance Our Understanding of Skin Diseases?
Kumaran, Girishkumar; Carroll, Liam; Muirhead, Nina; Bottomley, Matthew J.
Afiliación
  • Kumaran G; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Carroll L; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Muirhead N; Skin Inspection, London, United Kingdom.
  • Bottomley MJ; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address: matthew.bottomley@ndm.ox.ac.uk.
J Invest Dermatol ; 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39177547
ABSTRACT
Spatial transcriptomic (ST) profiling is the mapping of gene expression within cell populations with preservation of positional context and represents an exciting new approach to develop our understanding of local and regional influences upon skin biology in health and disease. With the ability to probe from a few hundred transcripts to the entire transcriptome, multiple ST approaches are now widely available. In this paper, we review the ST field and discuss its application to dermatology. Its potential to advance our understanding of skin biology in health and disease is highlighted through the illustrative examples of 3 research areas cutaneous aging, tumorigenesis, and psoriasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Invest Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Invest Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos