Your browser doesn't support javascript.
loading
The Effect of Periodontitis on Fibroblast Growth Factor 23 Levels in Predialysis Chronic Kidney Disease Patients.
Wan Abdul Azim, Wan Asma; Kassim, Nur Karyatee; Taib, Haslina; Abdullah, Nurul Huda; Che Abdul Aziz, Nur Amirah; Ibrahim, Hanim Afzan.
Afiliación
  • Wan Abdul Azim WA; Department of Chemical Pathology, Universiti Sains Malaysia School of Medical Sciences, Kubang Kerian, MYS.
  • Kassim NK; School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.
  • Taib H; Unit of Periodontics, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.
  • Abdullah NH; Department of Internal Medicine, Universiti Sains Malaysia School of Medical Sciences, Kubang Kerian, MYS.
  • Che Abdul Aziz NA; Department of Dentistry, Ministry of Health Malaysia, Putrajaya, MYS.
  • Ibrahim HA; School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.
Cureus ; 16(7): e65166, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39176315
ABSTRACT
Introduction Chronic kidney disease (CKD) is known to cause an increase in fibroblast growth factor 23 (FGF23). Periodontitis, a condition recognized as a risk factor for CKD, is also potentially associated with the increment of FGF23. This study aims to compare FGF23 levels in CKD patients with and without periodontitis and non-CKD patients with and without periodontitis. Correlation with serum phosphate, calcium, and intact parathyroid hormone (iPTH) was assessed. Additionally, associations between FGF23, calcium, phosphate, iPTH, creatinine, urea, plaque score, and bleeding score with periodontitis in CKD patients were determined. Method A total of 124 participants were categorized into four groups CKD patients with periodontitis (n=31), CKD patients without periodontitis (n=32), periodontitis patients without CKD (n=32), and healthy population (n=29). The selected CKD patients include those from stages 3 and 4 (predialysis) patients. Serum levels of FGF23, calcium, phosphate, iPTH, creatinine, and urea were analyzed. Oral examinations were conducted to determine the presence and absence of periodontitis and assess plaque and bleeding scores. Result A significantly higher level of FGF23 was found in CKD compared to non-CKD groups; however, no difference was observed with the presence of periodontitis in both CKD and non-CKD. There was no significant correlation found between FGF23 and serum calcium, phosphate, or iPTH concerning periodontal status. Apart from the bleeding score, there was no association between FGF23, calcium, phosphate, iPTH, creatinine, urea, and plaque score with the presence of periodontitis in CKD patients. Conclusion The presence of periodontitis was not associated with higher FGF23 levels in CKD patients. Changes in FGF23, calcium, phosphate, iPTH, creatinine, urea, and plaque score could not be attributed to the presence of periodontitis in CKD patients.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos