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Advantages of Curcuma longa in preventing male infertility caused by thioacetamide.
Jaber, Fatima A; Alaryani, Fatima S; Almutiri, Boudor S; Abdu, Suzan B; Mohammed, Arif.
Afiliación
  • Jaber FA; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
  • Alaryani FS; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
  • Almutiri BS; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
  • Abdu SB; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
  • Mohammed A; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Open Vet J ; 14(7): 1585-1595, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39175971
ABSTRACT

Background:

Thioacetamide (TAA) is known to cause damage to various organs, including the testes, posing a significant health threat. On the other hand, Curcuma longa (Cl) has been recognized for its antioxidant properties, suggesting a potential protective role against TAA-induced toxicity in the testes.

Aim:

This study aims to investigate the effect of TAA on testicular function and structure while exploring the therapeutic and protective potential of C. longa versus TAA toxicity.

Methods:

Thirty-two male albino rats, with an age range of 11-12 weeks and a weight range of 180-200 g, were randomly allocated into four distinct groups. The control group received normal saline, while the Cl group ingested Cl orally at a dose of 500 mg/kg daily. The TAA group, received TAA through intraperitoneal injections at a dose of 200 mg/kg body weight three times per week. Lastly, the Cl with TAA group received Cl orally 2 hours before the TAA injections. After 8 weeks of treatment, we anesthetized the rats and saved blood samples for biochemical analysis.

Results:

The study revealed significant alterations in various biochemical parameters in the TAA-treated group, as compared with the control. Specifically, there was a significant increase in bilirubin, albumin, cholesterol, triglyceride, very low-density lipoprotein, white blood cells, low-density lipoprotein cholesterol, and platelets levels. Conversely, the Cl-treated group exhibited significant reductions in these parameters, along with notable increases in red blood cells, high-density lipoprotein cholesterol, and hemoglobin.

Conclusion:

C. longa demonstrates a protective effect on the testes against TAA-induced toxicity, potentially attributed to its antioxidant properties. This suggests a promising avenue for the use of Cl in mitigating the harmful effects of TAA on testicular function and structure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testículo / Tioacetamida / Extractos Vegetales / Curcuma / Infertilidad Masculina Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Libia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testículo / Tioacetamida / Extractos Vegetales / Curcuma / Infertilidad Masculina Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Libia