Your browser doesn't support javascript.
loading
The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats.
Sucita, Ricky Eka; Fikri, Faisal; Purnomo, Agus; Maslamama, Salipudin Tasil; Purnama, Muhammad Thohawi Elziyad.
Afiliación
  • Sucita RE; Department of Veterinary Science, Faculty of Health, Medicine, and Life Sciences, Universitas Airlangga, Banyuwangi, Indonesia.
  • Fikri F; Department of Veterinary Science, Faculty of Health, Medicine, and Life Sciences, Universitas Airlangga, Banyuwangi, Indonesia.
  • Purnomo A; Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  • Maslamama ST; Department of Biology, Graduate School of Natural and Applied Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey.
  • Purnama MTE; Department of Veterinary Science, Faculty of Health, Medicine, and Life Sciences, Universitas Airlangga, Banyuwangi, Indonesia.
Open Vet J ; 14(7): 1561-1567, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39175965
ABSTRACT

Background:

Medical manifestations in the form of incisions, burns, and trauma will trigger a natural wound-healing process that involves complex interactions between cells. Brazilin and other secondary metabolites found in Sappan wood have numerous bioactive qualities, including anti-inflammatory, anti-cancer, and antioxidant properties.

Aim:

This study aimed to investigate the efficacy of Sappan wood (Caesalpinia Sappan L.) ethanol extract topically on the incision wound healing of albino rats.

Methods:

Twenty male rats were randomly assigned into five groups with four replications, i.e., (C-) was treated ointment-based, (C+) was treated with 10% povidone-iodine, (T1, T2, and T3 groups) were treated with Sappan wood extract concentration for 6.5%, 15%, and 30%, respectively. The treatment was topically administered to wounded areas twice a day for 15 days. Wound healing was evaluated histologically as the following parameters collagen deposition, polymorphonuclear neutrophils (PMN), angiogenesis, and fibrosis degree using H&E staining. IL-2 level was evaluated using the enzyme-linked immunosorbent assay (ELISA) method. Wound length reduction was calculated on days 8 and 15.

Results:

As a result, the 6.5% (T1), 15% (T2), and 30% (T3) Sappan wood extract groups were improved significantly (p < 0.05) compared to ointment-based (C-) and povidone-iodine (C+) groups on the collagen deposition, PMN, angiogenesis, fibrosis degree, and IL-2 level. In particular, the 6.5% (T1) Sappan wood extract group was highlighted significantly (p < 0.05) compared to other groups, evidenced by the improvisation of wound healing parameters and reduction of wound length on days 8 and 15.

Conclusion:

In conclusion, a 6.5% Sappan wood extract revealed its applicability to improve incision wound healing in albino rats.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Extractos Vegetales / Administración Tópica / Caesalpinia Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Libia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Extractos Vegetales / Administración Tópica / Caesalpinia Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Libia