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Oxygen-carrying semiconducting polymer nanoprodrugs induce sono-pyroptosis for deep-tissue tumor treatment.
Wang, Fengshuo; Fan, Yongliang; Liu, Yue; Lou, Xiangxin; Sutrisno, Linawati; Peng, Shaojun; Li, Jingchao.
Afiliación
  • Wang F; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical Engineering Donghua University Shanghai China.
  • Fan Y; Department of Cardiovascular Surgery Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  • Liu Y; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical Engineering Donghua University Shanghai China.
  • Lou X; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical Engineering Donghua University Shanghai China.
  • Sutrisno L; World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Tsukuba Japan.
  • Peng S; Zhuhai Institute of Translational Medicine Zhuhai Precision Medical Center Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University) Zhuhai Guangdong China.
  • Li J; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical Engineering Donghua University Shanghai China.
Exploration (Beijing) ; 4(4): 20230100, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39175882
ABSTRACT
Sonodynamic therapy (SDT) has been explored for cancer therapy, especially for deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited due to the complicated tumor microenvironment. This study reports the construction of oxygen-carrying semiconducting polymer nanoprodrugs (OSPNpro) for deep tumor treatment via combining amplified SDT with pyroptosis. An oxygen carrier perfluorohexane, sonodynamic semiconducting polymer as the sonosensitizer, and reactive oxygen species (ROS)-responsive prodrug are co-loaded into a nanoparticle system, leading to the formation of these polymer nanoprodrugs. Such OSPNpro show an effective accumulation in tumor tissues after systemic administration, in which they deliver oxygen to relieve tumor hypoxia microenvironment and thus mediate amplified SDT via producing ROS under ultrasound (US) irradiation, even when the tumors are covered with a 2-cm chicken breast tissue. In addition, the ROS-responsive prodrugs are activated by the generated ROS to trigger pyroptosis of tumor cells. Such a sono-pyroptosis induces a strong antitumor immunity with obviously higher level infiltrations of effector immune cells into tumors. Therefore, OSPNpro-based combinational therapy can greatly inhibit the growth of 2-cm chicken breast tissue-covered deep tumors and suppress tumor metastasis. This study offers a prodrug nanoplatform for treatment of deep tumor via sono-pyroptosis strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exploration (Beijing) Año: 2024 Tipo del documento: Article Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exploration (Beijing) Año: 2024 Tipo del documento: Article Pais de publicación: China