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Shortwave Infrared Imaging of a Quantum Dot-Based Magnetic Guidewire Toward Non-Fluoroscopic Peripheral Vascular Interventions.
Hwang, Junsun; Kim, Beomjoo; Jin, Chaewon; Lee, Gyudong; Jeong, Hwajun; Lee, Hyunki; Noh, Jonggu; Lim, Sung Jun; Kim, Jin-Young; Choi, Hongsoo.
Afiliación
  • Hwang J; Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.
  • Kim B; DGIST-ETH Microrobotics Research Center, DGIST, Daegu, 42988, Republic of Korea.
  • Jin C; Robotics and Mechatronics Engineering Research Center, DGIST, Daegu, 42988, Republic of Korea.
  • Lee G; Institute of Mechanical Engineering, École polytechnique fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.
  • Jeong H; Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.
  • Lee H; DGIST-ETH Microrobotics Research Center, DGIST, Daegu, 42988, Republic of Korea.
  • Noh J; Division of Biotechnology, DGIST, Daegu, 42988, Republic of Korea.
  • Lim SJ; DGIST-ETH Microrobotics Research Center, DGIST, Daegu, 42988, Republic of Korea.
  • Kim JY; Division of Nanotechnology, DGIST, Daegu, 42988, Republic of Korea.
  • Choi H; DGIST-ETH Microrobotics Research Center, DGIST, Daegu, 42988, Republic of Korea.
Small ; : e2404251, 2024 Aug 23.
Article en En | MEDLINE | ID: mdl-39175372
ABSTRACT
Peripheral vascular interventions (PVIs) offer several benefits to patients with lower extremity arterial diseases, including reduced pain, simpler anesthesia, and shorter recovery time, compared to open surgery. However, to monitor the endovascular tools inside the body, PVIs are conducted under X-ray fluoroscopy, which poses serious long-term health risks to physicians and patients. Shortwave infrared (SWIR) imaging of quantum dots (QDs) has shown great potential in bioimaging due to the non-ionizing penetration of SWIR light through tissues. In this paper, a QD-based magnetic guidewire and its system is introduced that allows X-ray-free detection under SWIR imaging and precise steering via magnetic manipulation. The QD magnetic guidewire contains a flexible silicone tube encapsulating a QD polydimethylsiloxane (PDMS) composite, where HgCdSe/HgS/CdS/CdZnS/ZnS/SiO2 core/multi-shell QDs are dispersed in the PDMS matrix for SWIR imaging upon near-infrared excitation, as well as a permanent magnet for magnetic steering. The SWIR penetration of the QD magnetic guidewire is investigated within an artificial tissue model (1% Intralipid) and explore the potential for non-fluoroscopic PVIs within a vascular phantom model. The QD magnetic guidewire is biocompatible in its entirety, with excellent resistance to photobleaching and chemical alteration, which is a promising sign for its future clinical implementation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania