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Association of Patient and Tumor Characteristics With Outcomes in Young Head and Neck Squamous Cell Carcinoma Patients.
Hsieh, Ronan W; Gooding, William E; Nilsen, Marci; Kubik, Mark; Kelly, Zahra; Sridharan, Shaum; Skinner, Heath; Iheagwara, Uzoma; Zevallos, Jose P; Duvvuri, Umamaheswar; Kim, Seungwon; Ferris, Robert L; Zandberg, Dan P.
Afiliación
  • Hsieh RW; Division of Hematology and Oncology, University of Washington School of Medicine, Seattle, WA, USA.
  • Gooding WE; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
  • Nilsen M; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Kubik M; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Kelly Z; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
  • Sridharan S; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Skinner H; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
  • Iheagwara U; Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Zevallos JP; Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Duvvuri U; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Kim S; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
  • Ferris RL; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Zandberg DP; Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Clin Otolaryngol ; 2024 Aug 22.
Article en En | MEDLINE | ID: mdl-39175141
ABSTRACT

INTRODUCTION:

We retrospectively studied young patients with head and neck squamous cell carcinoma (HNSCC) to identify factors associated with disease-specific survival (DSS).

METHODS:

Patient and tumor characteristics of patients aged ≤45 who received treatments for non-metastatic HNSCC were collected to identify factors associated with DSS. Proportional hazards regression was applied separately for surgical and non-surgical patients.

RESULTS:

230 patients were included. Surgical and non-surgical patients had similar DSS. Higher pathologic stages, positive margins, perineural invasion (PNI), extranodal extension and negative HPV status were associated with worse DSS for surgical patients and negative HPV status for non-surgical patients. In the multivariate analysis, pathologic stages, positive margins, and PNI were associated with worse DSS in surgical patients.

CONCLUSION:

Pathologic stages, positive margins, and PNI are independently associated with worse DSS in young surgical HNSCC patients. PNI is a uniquely strong prognostic factor for young patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Otolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Otolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido