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Acid-Resistant Nano-antioxidants Based on Epigallocatechin Gallate Alleviate Acute Intestinal and Kidney Inflammation.
Pan, Qingqing; Xie, Li; Cai, Pingyang; Wu, Di; Zhu, Huang; Xu, Long; Liu, Rong; Luo, Kui; He, Bin; Pu, Yuji.
Afiliación
  • Pan Q; School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
  • Xie L; School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
  • Cai P; College of Electronics and Information Engineering, Sichuan University, Chengdu 610065, China.
  • Wu D; Meat Processing Key Laboratory of Sichuan Province, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
  • Zhu H; School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
  • Xu L; School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.
  • Liu R; School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
  • Luo K; Huaxi MR Research Center, Department of Radiology, West China Hospital, Functional and Molecular Imaging Key Laboratory of Sichuan Province, Sichuan University, Chengdu 610041, China.
  • He B; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Med-X Center for Materials, Sichuan University, Chengdu 610064, China.
  • Pu Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Med-X Center for Materials, Sichuan University, Chengdu 610064, China.
ACS Appl Mater Interfaces ; 16(35): 46090-46101, 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39174346
ABSTRACT
Epigallocatechin gallate (EGCG)-based nanosystems have garnered significant attention for their ability to alleviate inflammation due to their excellent anti-inflammatory properties and enhanced drug delivery capabilities. However, the degradation of EGCG in strongly acidic environments poses a challenge for potential administration, particularly in oral formulations, where gastric resistance is essential. In this study, we develop a "disintegration and reorganization" strategy to create acid-resistant antioxidant nanoparticles (EGA NPs) based on EGCG and 5-aminosalicylic acid (5-ASA) for mitigating inflammation in colitis and acute kidney injury. At acidic pH, the ester bond in EGCG breaks down, producing two building blocks. These, together with 5-ASA and formaldehyde, form oligomers through a combination of phenol-aldehyde condensation and the Mannich reaction. The resulting oligomers self-assemble into EGA NPs, which exhibit significant stability under both acidic and neutral pH conditions. This stability makes them suitable for oral administration, allowing them to withstand harsh gastric conditions, as well as for intravenous injection. Importantly, these oligomers retain the antioxidant and anti-inflammatory properties of EGCG, effectively scavenging reactive oxygen species and reducing intracellular oxidative stress. Additionally, EGA shows potential as a drug carrier, efficiently loading the anti-inflammatory agent curcumin (Cur) to form Cur@EGA NPs. In vivo studies demonstrate the efficacy of Cur@EGA and EGA in alleviating acute colitis and kidney injury following oral and intravenous administration, respectively. These nanoparticulate formulations exhibit superior inflammation reduction compared to free Cur in vivo. Overall, our findings introduce a novel acid-resistant nanoplatform based on EGCG for the treatment of acute inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catequina / Nanopartículas / Lesión Renal Aguda / Antioxidantes Límite: Animals / Humans / Male Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catequina / Nanopartículas / Lesión Renal Aguda / Antioxidantes Límite: Animals / Humans / Male Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos