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Porcine epidemic diarrhea virus: A review of detection, inhibition of host gene expression and evasion of host innate immune.
Ma, Xiao; Zheng, Huihua; Chen, Hongying; Ma, Shijie; Wei, Zhanyong.
Afiliación
  • Ma X; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China.
  • Zheng H; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China; College of Animal Science and Technology and College of Veterinary Medicine of Zhejiang A&F University, China.
  • Chen H; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan, China. Electronic address:
  • Ma S; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan, China. Electronic address:
  • Wei Z; The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan, China.
Microb Pathog ; 195: 106873, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39173850
ABSTRACT
As one of the most important swine enteropathogenic coronavirus, porcine epidemic diarrhea virus (PEDV) is the causative agent of an acute and devastating enteric disease that causes lethal watery diarrhea in suckling piglets. Recent progress in studying PEDV has revealed many intriguing findings on its prevalence and genetic evolution, rapid diagnosis, suppression of host gene expression, and suppression of the host innate immune system. Due to the continuous mutation of the PEDV genome, viral evasions from innate immune defenses and mixed infection with other coronaviruses, the spread of the virus is becoming wider and faster, making it even more necessary to prevent the infections caused by wild-type PEDV variants. It has also been reported that PEDV nsp1 is an essential virulence determinant and is critical for inhibiting host gene expression by structural and biochemical analyses. The inhibition of host protein synthesis employed by PEDV nsp1 may contribute to the regulation of host cell proliferation and immune evasion-related biological functions. In this review, we critically evaluate the recent studies on these aspects of PEDV and assess prospects in understanding the function of PEDV proteins in regulating host innate immune response and viral virulence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Porcinos / Infecciones por Coronavirus / Virus de la Diarrea Epidémica Porcina / Evasión Inmune / Inmunidad Innata Límite: Animals Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Porcinos / Infecciones por Coronavirus / Virus de la Diarrea Epidémica Porcina / Evasión Inmune / Inmunidad Innata Límite: Animals Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido