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Unveiling the science behind erectile dysfunction topical therapy: investigating transdermal papaverine as a novel treatment approach.
Rezaiezadeh, Hojjat; Ranjbar Tavakoli, Marziyeh; Langarizadeh, Mohammad Amin; Saeedi Garaghani, Zahra; Karami-Mohajeri, Somayyeh.
Afiliación
  • Rezaiezadeh H; Student Research Committee, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
  • Ranjbar Tavakoli M; Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Langarizadeh MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
  • Saeedi Garaghani Z; Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
  • Karami-Mohajeri S; School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
Sex Med Rev ; 12(4): 720-730, 2024 Sep 25.
Article en En | MEDLINE | ID: mdl-39173091
ABSTRACT

INTRODUCTION:

Erectile dysfunction is among the most prevalent urologic issues affecting men globally and is characterized by a high incidence rate. This condition significantly affects the quality of life of patients and their sexual partners.

OBJECTIVES:

Due to the interactions, contraindications, and side effects associated with systemic drugs, recent research has increasingly focused on topical and transdermal medications for the treatment of erectile dysfunction.

METHODS:

Based on previous studies, this article examines papaverine in terms of local effectiveness, methods of increasing therapeutic efficiency, possible local side effects, and evaluation of its various formulations.

RESULTS:

Among these approaches, notable strategies include using novel formulations and nanoformulations as compared with classic ones, employing permeation enhancers, and combining treatments with other oral and topical drugs with synergistic mechanisms. These methods aim to improve transdermal papaverine's bioavailability and therapeutic efficacy while minimizing side effects and enhancing patient compliance.

CONCLUSION:

Transdermal papaverine may not be as effective as its injectable form, but the treatment path is more pleasant, with less pain and fewer side effects for patients. For this reason, using solutions that remove the penile skin and fascial absorption barrier can be very effective.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papaverina / Administración Cutánea / Disfunción Eréctil Límite: Humans / Male Idioma: En Revista: Sex Med Rev Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papaverina / Administración Cutánea / Disfunción Eréctil Límite: Humans / Male Idioma: En Revista: Sex Med Rev Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos