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A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth with Obesity.
Ha, Joon; Kim, Joon Young; Springer, Max; Chhabra, Aaryan; Chung, Stephanie T; Sumner, Anne E; Sherman, Arthur; Arslanian, Silva.
Afiliación
  • Ha J; Department of Mathematics, Howard University, Washington, DC.
  • Kim JY; Department of Exercise Science, David B. Falk College of Sport and Human Dynamics, Syracuse University, Syracuse, NY.
  • Springer M; Department of Mathematics, University of Maryland.
  • Chhabra A; Department of Biology, Indian Institute of Science Education and Research Pune  Maharashtra 411008, India.
  • Chung ST; Section on Pediatric Diabetes, Obesity, and Metabolism, NIDDK, NIH, Bethesda, MD.
  • Sumner AE; Intramural Research Program, National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health, Bethesda, MD.
  • Sherman A; Section on Ethnicity and Health, Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD.
  • Arslanian S; Hypertension in Africa Research Team, North-West University, Potchefstroom, North-West, South Africa.
J Clin Endocrinol Metab ; 2024 Aug 22.
Article en En | MEDLINE | ID: mdl-39172553
ABSTRACT

AIMS:

The gold standard clamp measurements for insulin sensitivity (cSI), ß-cell function (cBCF) and disposition index (cDI = cSI*cBCF), are not practical in large-scale studies. We sought to 1) validate a mathematical model-derived DI from oral glucose tolerance tests (OGTT) with insulin (mDI) and without (mDI-woI) against cDI and oral disposition index (oDI) evaluate the ability of the novel indices to detect prediabetes and type 2 diabetes.

METHODS:

We carried out a secondary analysis of previously reported cross-sectional observational studies. The Insulin Sensitivity and Secretion mathematical model for glucose-insulin dynamics was applied to five-point and three-point OGTTs synchronized with hyperinsulinemic-euglycemic and hyperglycemic clamps from 130 youth with obesity (68 NGT, 33 IGT, 29 T2D).

RESULTS:

Model-derived DI correlated well with clamp DI (R = 0.76 (logged)). Between NGT and IGT, mDI and mDI-woI decreased more than oDI and cDI, (60 and 59% vs 29 and 27%), and by receiver operating characteristic (ROC) analysis were superior at detecting IGT than oDI and cDI (AUC 0.88, 0.87 vs 0.68, 0.65), as was mean glucose (AUC 0.87).

CONCLUSIONS:

mDI-woI is better than oDI or the labor-intensive cDI for detecting dysglycemia in obese youth. Bypassing insulin measurements with mDI-woI from the OGTT provides a cost-effective approach for large-scale epidemiological studies of dysglycemia in youth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos