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Real-world data on the prevalence of BRCA1/2 and HRR gene mutations in patients with primary and metastatic castration resistant prostate cancer.
Hommerding, Moritz; Hommerding, Oliver; Bernhardt, Marit; Kreft, Tobias; Sanders, Christine; Tischler, Verena; Basitta, Patrick; Pelusi, Natalie; Wulf, Anna-Lena; Ohlmann, Carsten-Henning; Ellinger, Jörg; Ritter, Manuel; Kristiansen, Glen.
Afiliación
  • Hommerding M; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Hommerding O; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Bernhardt M; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Kreft T; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Sanders C; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Tischler V; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Basitta P; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Pelusi N; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Wulf AL; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany.
  • Ohlmann CH; Department of Urology, Johanniter-Kliniken Bonn, Bonn, Germany.
  • Ellinger J; Department of Urology, University Hospital Bonn, Bonn, Germany.
  • Ritter M; Department of Urology, University Hospital Bonn, Bonn, Germany.
  • Kristiansen G; Institute of Pathology, University Hospital Bonn (UKB), Venusberg-Campus 1, Bonn, 53127, Germany. glen.kristiansen@ukbonn.de.
World J Urol ; 42(1): 491, 2024 Aug 22.
Article en En | MEDLINE | ID: mdl-39172235
ABSTRACT

PURPOSE:

This study seeks to contribute real-world data on the prevalence of BRCA1/2 and HRR gene mutations in prostate cancer.

METHODS:

We compiled sequencing data of 197 cases of primary and metastatic prostate cancer, in which HRR mutation analysis was performed upon clinical request within the last 5 years. All cases were analyzed using a targeted NGS BRCAness multigene panel, including 8 HRR genes (ATM, BRCA1, BRCA2, CDK12, CHEK2, FANCA, HDAC2, PALB2).

RESULTS:

Our findings reveal a prevalence of potentially targetable mutations based on FDA criteria of 20.8%, which is comparable to the literature. However, the frequency of targetable BRCA2 mutations within our cohort was lower than reported for mCRPC and ATM and CHEK2 mutations were more prevalent instead. Thus, while 20.8% (n = 38) of the cases meet the criteria for olaparib treatment per FDA approval, only 4.9% (n = 9) align with the eligibility criteria according to the EMA approval.

CONCLUSION:

This study offers valuable real-world insights into the landscape of BRCA1/2 and HRR gene mutations and the practical clinical management of HRR gene testing in prostate cancer, contributing to a better understanding of patient eligibility for PARPi treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína BRCA1 / Proteína BRCA2 / Neoplasias de la Próstata Resistentes a la Castración Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: World J Urol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína BRCA1 / Proteína BRCA2 / Neoplasias de la Próstata Resistentes a la Castración Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: World J Urol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania