Synthesis of 5-Trifluoromethyl-1,3-thiazin-4-one Compounds using Trifluoromethyl Acrylic Acid as a Synthon.

Huang, Zhilong; Yang, Hao; Lai, Xubo; Li, Jin; Yang, Weiran; Zheng, Jing

Huang, Zhilong; Yang, Hao; Lai, Xubo; Li, Jin; Yang, Weiran; Zheng, Jing.

Afiliación

Huang Z; School of Chemistry and Chemical Engineering, Nanchang University, 999 XueFu Road, Nangchang 330031, China.
Yang H; School of Chemistry and Chemical Engineering, Nanchang University, 999 XueFu Road, Nangchang 330031, China.
Lai X; School of Chemistry and Chemical Engineering, Nanchang University, 999 XueFu Road, Nangchang 330031, China.
Li J; School of Chemistry and Chemical Engineering, Nanchang University, 999 XueFu Road, Nangchang 330031, China.
Yang W; School of Chemistry and Chemical Engineering, Nanchang University, 999 XueFu Road, Nangchang 330031, China.
Zheng J; School of Chemistry and Chemical Engineering, Nanchang University, 999 XueFu Road, Nangchang 330031, China.

J Org Chem ; 89(17): 12387-12391, 2024 Sep 06.

Article en En | MEDLINE | ID: mdl-39171827

ABSTRACT

ABSTRACT

A novel method has been developed for the synthesis of 1,3-thiazin-4-one compounds containing trifluoromethyl groups utilizing 2-trifluoromethyl acrylic acid and thioamides as key starting materials. This protocol is characterized by its simplicity, practicality, and tolerance toward various functional groups. Given the straightforward nature of the procedure, the ready availability of both starting materials, and the significance of drugs containing trifluoromethyl, it is anticipated that this reaction will have wide-ranging applications.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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