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Key Questions and Gaps in Understanding Adipose Tissue Macrophages and Early-Life Metabolic Programming.
Hill, Kaitlyn; Mullen, Gregory P; Nagareddy, Prabha; Zimmerman, Kurt; Rudolph, Michael C.
Afiliación
  • Hill K; Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
  • Mullen GP; Harold Hamm Diabetes Center and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
  • Nagareddy P; Internal Medicine, Section of Cardiovascular Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
  • Zimmerman K; Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
  • Rudolph MC; Harold Hamm Diabetes Center, Dept of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Am J Physiol Endocrinol Metab ; 2024 Aug 22.
Article en En | MEDLINE | ID: mdl-39171752
ABSTRACT
The global obesity epidemic, with its associated comorbidities and increased risk of early mortality, underscores the urgent need for enhancing our understanding of the origins of this complex disease. It is increasingly clear that metabolism is programmed early in life and that metabolic programming can have life-long health consequences. As a critical metabolic organ sensitive to early-life stimuli, proper development of adipose tissue (AT) is crucial for life-long energy homeostasis. Early-life nutrients, especially fatty acids (FA), significantly influence the programming of AT and shape its function and metabolism. Of growing interest are the dynamic responses during pre- and postnatal development to proinflammatory omega-6 (n6) and anti-inflammatory omega-3 (n3) FA exposures in AT. In the US maternal diet, the ratio of 'pro-inflammatory' n6- to 'anti-inflammatory' n3-FA has grown dramatically due to the greater prevalence of n6-FA. Notably, AT macrophages (ATM) form a significant population within adipose stromal cells, playing not only an instrumental role in AT formation and maintenance, but also acting as key mediators of cell-to-cell lipid and cytokine signaling. Despite rapid advances in ATM and immunometabolism fields, research has focused on responses to obesogenic diets and during adulthood. Consequently, there is a significant gap in identifying the mechanisms contributing metabolic health, especially regarding lipid exposures during the establishment of ATM physiology. Our review highlights the current understanding of ATM diversity, their critical role in AT, and their potential role in early-life metabolic programming, as well as the broader implications for metabolism and health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos