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Protective Effects of Chitosan-Loaded Pomegranate Peel Extract Nanoparticles on Infertility in Diabetic Male Rats.
Said, Farah; Omar, Amel Ramadan; Mohamed, Ayman Saber; Dakrory, Ahmed Imam; Abdelaziz, Mennatallah H.
Afiliación
  • Said F; Zoology Department, Faculty of Science; Cairo University, Giza, 12613, Egypt.
  • Omar AR; Zoology Department, Faculty of Science; Cairo University, Giza, 12613, Egypt.
  • Mohamed AS; Zoology Department, Faculty of Science; Cairo University, Giza, 12613, Egypt.
  • Dakrory AI; Zoology Department, Faculty of Science; Cairo University, Giza, 12613, Egypt.
  • Abdelaziz MH; Zoology Department, Faculty of Science; Cairo University, Giza, 12613, Egypt.
Curr Top Med Chem ; 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39171473
ABSTRACT

BACKGROUND:

Diabetes Mellitus (DM) is known to have an impact on the health of the male reproductive system. It is linked to low sperm quality, increased oxidative stress, and an increased generation of reactive oxygen species in the seminal fluid. Pomegranate extract has phenolic compounds and significant protective properties against oxidative stress, male sex hormone disruptions, and sperm abnormalities.

OBJECTIVE:

The current study aimed to evaluate the effectiveness of Pomegranate Peel Extract Nanoparticles (PPENPs) on male fertility in diabetic rats.

METHODS:

DM was induced in rats by intraperitoneal injection of streptozotocin (60 mg/kg). Twenty-four rats were divided into four groups, 6 rats in each group control, DM, DM+empty NPs (60 mg/kg, orally), and DM+PPENPs (60 mg/kg, orally).

RESULTS:

Administration of PPENPs increased the levels of insulin, FSH, LH, testosterone, catalase, glutathione reduced, and semen fructose. PPENPs also improved sperm quality, as seen by improvements in sperm morphology, motility, count, and the ability of metabolically active spermatozoa to convert blue resazurin dye to pink resorufin. However, PPENPs decreased levels of glucose, malonaldehyde, nitric oxide, and sperm abnormalities. Also, histological investigation of the PPENPs showed improvement in testis tissue architecture and increased the diameter size of seminiferous tubules and germinative layer thickness.

CONCLUSION:

Our investigation proved that the treatment of PPENPs has a protective effect on the reproductive system of male diabetic rats, improving fertility parameters, healthy sperm profiles, and the antioxidant system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Emiratos Árabes Unidos