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Soursop leaf extract and fractions protects against L-NAME-induced hypertension and hyperlipidemia.
Nsor, Okim Okim; Alabi, Babatunde Adebola; Badejo, Joseph Ayo; Afolabi, Faith; Nku-Ekpang, Okot-Asi; Iwalewa, Ezekiel Olugbenga.
Afiliación
  • Nsor OO; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Alabi BA; Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Bowen University, Iwo, Nigeria.
  • Badejo JA; Department of Pharmacology and Therapeutics, Faculty of Medicine and Pharmacy, Kampala International University in Tanzania, Dar es Salaam, Tanzania.
  • Afolabi F; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Nku-Ekpang OA; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Iwalewa EO; Department of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria.
Front Nutr ; 11: 1437101, 2024.
Article en En | MEDLINE | ID: mdl-39171117
ABSTRACT

Introduction:

Despite the high phenolic content of Annona muricata, little is known about its anti-hypertensive and antihyperlipidemic properties. This study evaluated the anti-hypertensive and antihyperlipidemic potential of A. muricata leaf extracts. Materials and

methods:

Forty-two male Wistar rats were divided into seven groups of six animals each. N-nitro-L-arginine methyl ester (L-NAME) was used to induce hypertension and hyperlipidemia.

Results:

Phytochemical screening of Annona muricata leaf extracts (AMLE) revealed the presence of saponins, alkaloids, flavonoids, tannins, coumarins, steroids, terpenoids, and phenols. Comparing the methanol extract with the ethyl acetate fraction, quantification revealed that the methanol extract contained more phenolics, flavonoids, and alkaloids. The AMLE rats significantly reduced triglycerides, total cholesterol, LDL, VLDL, atherogenic index, coronary risk index, and blood pressure. The significant decrease in GSH, catalase, SOD, GST, and oxidative stress markers (MDA, nitrites, and MPO) was reversed by AMLE in a dose-dependent manner. Also, the elevated serum levels of TNF-α and IL-1ß in the hypertensive rats were attenuated in the treatment groups.

Discussion:

This study suggests the potential ameliorative effects of Annona muricata leaf extracts against L-NAME-induced hypertension in rats. Notably, the study showed the antioxidant and anti-inflammatory properties of A. muricata leaf extracts, which is seen in its ability to attenuate oxidative stress and inflammatory cytokines in L-NAME-induced hypertensive rats. A. muricata extracts also decreased atherogenic risk and improved lipid profiles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Suiza