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The association of different types of human milk with bronchopulmonary dysplasia in preterm infants.
Pütz, Elisabeth; Ascherl, Rudolf; Wendt, Thomas; Thome, Ulrich H; Gebauer, Corinna; Genuneit, Jon; Siziba, Linda P.
Afiliación
  • Pütz E; Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Ascherl R; Division of Neonatology, Department of Pediatrics, University of Leipzig Medical Center, Leipzig, Germany.
  • Wendt T; Data Integration Center, University of Leipzig Medical Center, Leipzig, Germany.
  • Thome UH; Division of Neonatology, Department of Pediatrics, University of Leipzig Medical Center, Leipzig, Germany.
  • Gebauer C; Division of Neonatology, Department of Pediatrics, University of Leipzig Medical Center, Leipzig, Germany.
  • Genuneit J; Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Siziba LP; German Center for Child and Youth Health (DZKJ), Leipzig, Germany.
Front Nutr ; 11: 1408033, 2024.
Article en En | MEDLINE | ID: mdl-39171103
ABSTRACT

Objective:

To evaluate the association between different types of human milk feeds and bronchopulmonary dysplasia (BPD) in preterm infants.

Methods:

Data on dispensed mother's own milk (MOM) and donor human milk (DHM) from Leipzig Milk Bank for hospitalized infants with a gestational age (GA) ≤32 weeks observed from birth to 36 weeks' postmenstrual age or prior discharge were used. BPD was assessed based on documented International Statistical Classification of Diseases and Related Health Problems (ICD) diagnosis and on electronic hospital records (EHR) of data on ventilation and oxygen supplementation. Associations of dispensed milk feed variations with BPD were investigated using logistic regressions in crude and adjusted models.

Results:

866 infants were included with a BPD prevalence of 15.4% (EHR) and 23.2% (ICD). The mean GA was 29.1 weeks. The majority (84.4%, n = 746) of infants were nurtured with a mix of MOM, DHM supplemented by formula or parenteral (other) nutrition during hospitalization. For which, MOM comprised the highest median [Q1-Q3] percentage proportion (53[31-81] %) of this mix. Exclusive fresh milk and exclusive MOM feeds were dispensed on a mean of 40 and 34% patient-days, respectively. Statistically significant associations with lower BPD incidence were only observed for 70-80% MOM vs. DHM, and 60% fresh vs. frozen milk, in crude and adjusted models.

Conclusion:

Our findings suggest a protective association of MOM and fresh milk with lower odds of BPD, which may be dependent on the proportion of MOM or fresh milk administered. These results highlight the importance of MOM as an ideal source of nutrition during early infancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza