Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance.
Chin Med J Pulm Crit Care Med
; 2(1): 42-47, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-39170959
ABSTRACT
Lung cancer is a leading cause of cancer deaths worldwide, consisting of two major histological subtypes small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). In some cases, NSCLC patients may undergo a histological transformation to SCLC during clinical treatments, which is associated with resistance to targeted therapy, immunotherapy, or chemotherapy. The review provides a comprehensive analysis of SCLC transformation from NSCLC, including biological mechanism, clinical relevance, and potential treatment options after transformation, which may give a better understanding of SCLC transformation and provide support for further research to define better therapy options.
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Colección:
01-internacional
Base de datos:
MEDLINE
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En
Revista:
Chin Med J Pulm Crit Care Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Países Bajos