Single nucleotide variants in lung cancer.

Tian, Xiaoling; Liu, Zhe

Tian, Xiaoling; Liu, Zhe.

Afiliación

Tian X; Zhejiang Key Laboratory of Medical Epigenetics, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Liu Z; Zhejiang Key Laboratory of Medical Epigenetics, Department of Cell Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Chin Med J Pulm Crit Care Med ; 2(2): 88-94, 2024 Jun.

Article en En | MEDLINE | ID: mdl-39169933

ABSTRACT

ABSTRACT

Germline genetic variants, including single-nucleotide variants (SNVs) and copy number variants (CNVs), account for interpatient heterogeneity. In the past several decades, genome-wide association studies (GWAS) have identified multiple lung cancer-associated SNVs in Caucasian and Chinese populations. These variants either reside within coding regions and change the structure and function of cancer-related proteins or reside within non-coding regions and alter the expression level of cancer-related proteins. The variants can be used not only for cancer risk assessment and prevention but also for the development of new therapies. In this review, we discuss the lung cancer-associated SNVs identified to date, their contributions to lung tumorigenesis and prognosis, and their potential use in predicting prognosis and implementing therapeutic strategies.

Palabras clave

Germline mutation; Lung cancer; Outcome; Precision medicine; Single nucleotide variants; Susceptibility

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chin Med J Pulm Crit Care Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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