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Impact of liposomal hesperetin in broilers: prospects for improving performance, antioxidant potential, immunity, and resistance against Listeria monocytogenes.
Abd El-Hamid, Marwa I; El-Malt, Rania M S; Khater, Safaa I; Abdelwarith, Abdelwahab A; Khamis, Tarek; Abd El-Wahab, Reham A; Younis, Elsayed M; Davies, Simon J; Ibrahim Mohamed, Dalia; Mohamed, Rania I; Zayed, Shimaa; Abdelrahman, Mahmoud A; Ibrahim, Doaa.
Afiliación
  • Abd El-Hamid MI; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • El-Malt RMS; Department of Bacteriology, Animal Health Research Institute (AHRI), Zagazig Branch, Agriculture Research Center (ARC), Zagazig, Egypt.
  • Khater SI; Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • Abdelwarith AA; Department of Zoology, College of Science, King Saudi University, Riyadh, Saudi Arabia.
  • Khamis T; Department of Pharmacology and Laboratory of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • Abd El-Wahab RA; Biochemistry Department, Animal Health Research Institute (AHRI), Mansoura Branch, Agriculture Research Center (ARC), Giza, Egypt.
  • Younis EM; Department of Zoology, College of Science, King Saudi University, Riyadh, Saudi Arabia.
  • Davies SJ; Aquaculture Nutrition Research Unit (ANRU), Carna Research Station, College of Science and Engineering, Ryan Institute, University of Galway, Galway, Ireland.
  • Ibrahim Mohamed D; Department of Biochemistry, Animal Health Research Institute, Zagazig Branch, Agriculture Research Center, Zagazig, Egypt.
  • Mohamed RI; Department of Pathology, Agricultural Research Center (ARC), Animal Health Research Institute, Mansoura Provincial Laboratory (AHRI-Mansoura), Cairo, Egypt.
  • Zayed S; Biochemistry Department, Animal Health Research Institute (AHRI), Mansoura Branch, Agriculture Research Center (ARC), Giza, Egypt.
  • Abdelrahman MA; Bacteriology Department, Animal Health Research Institute (AHRI), Mansoura Branch, Agriculture Research Center (ARC), Giza, Egypt.
  • Ibrahim D; Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Avian Pathol ; : 1-29, 2024 Sep 09.
Article en En | MEDLINE | ID: mdl-39169883
ABSTRACT
Liposomal encapsulated phytogenics, such as liposomal hesperetin, are considered novel substitutes for antibiotics in the broiler industry owing to their improved nutritional and therapeutic properties. Therefore, our key goal was to investigate liposomal hesperetin impact on broiler growth performance, health, antioxidant status, tight junction proteins (TJP), and resistance against Listeria monocytogenes. Four broiler groups were fed 0, 150, 250, or 400 mg/kg of liposomal hesperetin-supplemented diets and experimentally infected with L. monocytogenes strain. Herein, liposomal hesperetin, especially at higher concentrations, augmented broilers FCR with upregulation of genes encoding TJP (occludin, JAM-2, MUC-2), and antioxidant attributes (GPX-1, SOD-1, CAT, HO-1, NQO1, COX2), which reflect enhancing health and welfare of broilers. Muscle antioxidant biomarkers were enhanced; meanwhile, muscle MDA, ROS, and H2O2 levels were reduced in response to 400 mg/kg of liposomal hesperetin. Liposomal hesperetin fortification reduced L. monocytogenes loads and expression levels of its virulence-related genes (flaA, hlyA, and ami). Remarkably, histopathological alterations in intestinal and brain tissues of L. monocytogenes-infected broilers were restored post-inclusion at higher levels of liposomal hesperetin, which reflects increase of the birds' resistance to L. monocytogenes infection. Transcription levels of genes encoding cytokines/chemokines (MyD88, AVBD6, CCL20, IL-1ß, IL-18), and autophagy (Bcl-2, LC3, AMPK, AKT, CHOP, Bip, p62, XBP1) were ameliorated following dietary liposomal hesperetin fortification, which suggests enhancement of the birds' immunity and health. Collectively, our research recommends liposomal hesperetin application in broiler diets owing to its promoting impact on growth performance, antioxidant status, immunity, health, and welfare besides its antibacterial, and antivirulence characteristics to fight against L. monocytogenes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Avian Pathol Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Avian Pathol Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido