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Intranasal Trigeminal Function in Aging Adults.
Feit, Noah Z; Kloosterman, Nicole; LaPointe, Kristina A; Pitiranggon, Charn; Finnegan, Isabel E; Smith, Carter D; Gregoski, Mathew J; Rowan, Nicholas R; Soler, Zachary M; Schlosser, Rodney J.
Afiliación
  • Feit NZ; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • Kloosterman N; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • LaPointe KA; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • Pitiranggon C; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • Finnegan IE; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • Smith CD; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • Gregoski MJ; Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
  • Rowan NR; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
  • Soler ZM; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
  • Schlosser RJ; Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
Am J Rhinol Allergy ; : 19458924241274973, 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39169723
ABSTRACT

BACKGROUND:

Intranasal trigeminal function is important in detecting environmental stimuli. The impact of age-associated chemosensory dysfunction upon taste and olfaction is well described, but an understanding of trigeminal loss (chemesthesis) is lacking.

OBJECTIVE:

The goal of this study was to characterize trigeminal function in a cohort of older adults and explore potential impacts.

METHODS:

Twenty-eight participants over 50 years of age were recruited from the community as part of an aging cohort study. This nested cohort completed chemosensory questionnaires, patient-reported outcome measures (PROMs), and psychophysical testing for taste (taste strips), olfaction (Sniffin' Sticks), and trigeminal function (eucalyptol lateralization). Data were analyzed for associations between trigeminal function, olfactory, and taste psychophysical performance, patient-reported metrics, and demographic risk factors.

RESULTS:

Patient-reported trigeminal impairment is less severe than other chemosensory loss, with mean visual analog scores (VAS, rated 0-100 from least to most severe) for smell (32.9 ± 34.2), taste (20.6 ± 28.4), and trigeminal sensation (9.5 ± 12.8). Despite low VAS scores, psychophysical trigeminal dysfunction was present in 10 (35.7%) subjects. Psychophysical olfactory and taste dysfunction were present in 16 (57.1%) and eight (28.6%) participants respectively. Hypercholesterolemia was associated with psychophysical trigeminal dysfunction (mean lateralization performance in hypercholesterolemia 57.7% ± 17.1 vs. 74.1% ± 10.4, p = .008).

CONCLUSION:

Intranasal trigeminal impairment is present in nearly one-third of aging adults when assessed by psychophysical methods but is under-recognized. Hyperlipidemia may be associated with trigeminal impairment. Future inquiries should better characterize these findings in larger and prospective cohorts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Rhinol Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA / OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Rhinol Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA / OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos