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Bioimpedance analysis of fat free mass and its subcomponents and relative associations with maximal oxygen consumption in facioscapulohumeral dystrophy.
Crisafulli, Oscar; Bottoni, Giorgio; Lacetera, Jessica; Fassio, Federico; Grattarola, Luca; Lavaselli, Emanuela; Giovanetti, Giuseppe; Tupler, Rossella; Negro, Massimo; D'Antona, Giuseppe.
Afiliación
  • Crisafulli O; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
  • Bottoni G; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
  • Lacetera J; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
  • Fassio F; BioData Science Unit, IRCCS Mondino Foundation, 27100, Pavia, Italy.
  • Grattarola L; Department of Public Health, Experimental and Forensic Medicine, Section of Biostatistics and Clinical Epidemiology, University of Pavia, 27100, Pavia, Italy.
  • Lavaselli E; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
  • Giovanetti G; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
  • Tupler R; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
  • Negro M; Department of Life Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.
  • D'Antona G; CRIAMS-Sport Medicine Centre Voghera, University of Pavia, 27058, Voghera, Italy.
Eur J Appl Physiol ; 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39168898
ABSTRACT

PURPOSE:

Fat free mass (FFM) is considered the metabolically active component of human body and is positively associated with maximal oxygen uptake ( VO 2 max ). However, FFM is composed of metabolically active and inactive subcomponents whose proportion can vary depending on body composition and clinical condition, possibly affecting such association. Although it is known that in facioscapulohumeral dystrophy (FSHD) peculiar changes in body composition occur, it is unclear whether there are alterations in FFM composition and, if so, whether such alterations affect the association towards VO 2 max compared to healthy subjects (HS).

METHODS:

To address this issue, 27 FSHD patients (mean age 37.3; 9 female) and 27 sex and age matched HS, underwent an assessment of VO 2 max by cardiopulmonary exercise tests (CPET) and body composition, with reference to FFM and its subcomponents, by bioimpedance analysis.

RESULTS:

In between-groups comparison, patients showed lower amounts of body cell mass (BCM) and intracellular water (ICW) which reflect in lower BCM/FFM ratio and higher extracellular to intracellular water ratio (ECW/ICW). Patients' VO 2 max was lower than HS and, even if with lower associative values than HS, correlated with FFM and BCM, while BCM/FFM and ECW/ICW ratios associations were observed only in HS.

CONCLUSION:

FSHD patients showed lower amount of BCM and ICW. BCM resulted as the parameter with the highest associative value with VO2max in both groups. Since VO 2 max is associated with functional ability in dystrophic patients, BCM, rather than FFM, could be an additional body composition-based clinical stratification factor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania