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The electro-responsive nanoliposome as an on-demand drug delivery platform for epilepsy treatment.
Sabet, Fereshte Sadat; Dabirmanesh, Bahareh; Sabet, Hoorie Sadat; Zarei, Parisa; Hosseini, Morteza; Fathollahi, Yaghoub; Khajeh, Khosro.
Afiliación
  • Sabet FS; Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran. Electronic address: fereshte.sabet@modares.ac.ir.
  • Dabirmanesh B; Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran. Electronic address: dabirmanesh@modares.ac.ir.
  • Sabet HS; Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran. Electronic address: hoorie.sabet@ut.ac.ir.
  • Zarei P; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: Parisa.zareie@modares.ac.ir.
  • Hosseini M; Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran. Electronic address: hosseini_m@ut.ac.ir.
  • Fathollahi Y; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: fatolahi@modares.ac.ir.
  • Khajeh K; Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran; Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran. Electronic address: khajeh@modares.ac.ir.
Int J Pharm ; 664: 124610, 2024 Oct 25.
Article en En | MEDLINE | ID: mdl-39168285
ABSTRACT
Nano-based drug delivery systems are regarded as a promising tool for efficient epilepsy treatment and seizure medication with the least general side effects and socioeconomic challenges. In the current study, we have designed a smart nanoscale drug delivery platform and applied it in the kindling model of epilepsy that is triggered rapidly by epileptic discharges and releases anticonvulsant drugs in situ, such as carbamazepine (CBZ). The CBZ-loaded electroactive ferrocene nanoliposomes had an average diameter of 100.6 nm, a surface charge of -7.08 mV, and high drug encapsulation efficiency (85.4 %). A significant increase in liposome size was observed in response to direct current (50-500 µA) application. This liposome-based drug delivery system can release CBZ at a fast rate in response to both direct current and pulsatile electrical stimulation in vitro. The CBZ-liposome can release the anticonvulsant drug upon epileptiform activity in the kindled rat model and can decline electrographic and behavioral seizure activity in response to electrical stimulation of the hippocampus with an initially subconvulsive current. With satisfactory biosafety results, this "smart" nanocarrier has promising potential as an effective and safe drug delivery system to improve the therapeutic index of antiepileptic drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbamazepina / Sistemas de Liberación de Medicamentos / Epilepsia / Liposomas / Anticonvulsivantes Límite: Animals Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbamazepina / Sistemas de Liberación de Medicamentos / Epilepsia / Liposomas / Anticonvulsivantes Límite: Animals Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos