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Effects on Gait and Balance of VIM Gamma Knife Radiosurgery in Essential Tremor.
Mira, Valentin; Zwaard, Babette; Boutin, Emmanuelle; Guillaud, Etienne; Cretol, Axelle; Régis, Jean; Azulay, Jean-Philippe; Witjas, Tatiana; Vaugoyeau, Marianne.
Afiliación
  • Mira V; AMU-CRNS, Centre de recherche en psychologie et neurosciences, Marseille, France.
  • Zwaard B; Timone Hospital Department of Neurology and Pathology of Movement, Marseille, France.
  • Boutin E; AMU-CRNS, Centre de recherche en psychologie et neurosciences, Marseille, France.
  • Guillaud E; Timone Hospital Department of Neurology and Pathology of Movement, Marseille, France.
  • Cretol A; University of Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Bordeaux, France.
  • Régis J; Department of Functional and Stereotactic Neurosurgery, Timone Hospital, Marseille, France.
  • Azulay JP; Department of Functional and Stereotactic Neurosurgery, Timone Hospital, Marseille, France.
  • Witjas T; AMU-CRNS, Centre de recherche en psychologie et neurosciences, Marseille, France.
  • Vaugoyeau M; Timone Hospital Department of Neurology and Pathology of Movement, Marseille, France.
Stereotact Funct Neurosurg ; : 1-9, 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39168114
ABSTRACT

INTRODUCTION:

Essential tremor (ET) is the most common movement disorder, characterized by an action tremor in the upper limbs. Neurosurgical techniques targeting the thalamic ventrointermediate nucleus (VIM) including thermocoagulation demonstrated a potential risk for gait and posture worsening. This study evaluates the potential effect of VIM Gamma Knife radiosurgery (GKR) in ET on gait and posture performances.

METHODS:

We conducted a prospective study to quantitatively assess gait and balance in severe ET patients before and 1 year after unilateral GKR. Seventy-three patients were included in this series.

RESULTS:

First, we confirmed the unilateral GKR efficacy in severe ET patients global tremor score and impairments in activities of daily living improved, respectively, by 67% and 71.7%. The global gait and posture analysis found no significant differences before and 1 year after GKR. Three patients (4.1%) developed mild to moderate gait and posture impairment with proprioceptive ataxia. All of these AEs were induced by a hyper-response to radiosurgery.

CONCLUSIONS:

Gait and posture performances were not statistically significant at the population. Nevertheless, gait and posture worsened in 4% of patients after GKR, all in the setting of hyper-response. This study shows that GKR may be a safe neurosurgical alternative to improve ADL in a population of patients with TE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Stereotact Funct Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Stereotact Funct Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza