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Pneumococcal carriage and changes in serotype distribution post- PCV13 introduction in children in Matiari, Pakistan.
Iqbal, Izn; Shahid, Shahira; Kanwar, Samiah; Kabir, Furqan; Umrani, Fayaz; Ahmed, Sheraz; Khan, Waqasuddin; Qazi, Muhammad Farrukh; Aziz, Fatima; Muneer, Sahrish; Kalam, Adil; Hotwani, Aneeta; Mehmood, Junaid; Qureshi, Abdul Khalique; Hasan, Zahra; Shakoor, Sadia; Mirza, Shaper; McGee, Lesley; Lo, Stephanie W; Kumar, Narender; Azam, Iqbal; Bentley, Stephen D; Jehan, Fyezah; Nisar, Muhammad Imran.
Afiliación
  • Iqbal I; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Shahid S; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Kanwar S; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Kabir F; Infectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Umrani F; Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
  • Ahmed S; Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
  • Khan W; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Qazi MF; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Aziz F; Infectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Muneer S; Infectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Kalam A; Infectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Hotwani A; Infectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Mehmood J; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Qureshi AK; Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
  • Hasan Z; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
  • Shakoor S; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
  • Mirza S; Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan.
  • McGee L; Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Lo SW; Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
  • Kumar N; Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
  • Azam I; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Bentley SD; Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
  • Jehan F; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Nisar MI; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: imran.nisar@aku.edu.
Vaccine ; 42(23): 126238, 2024 Oct 03.
Article en En | MEDLINE | ID: mdl-39168078
ABSTRACT

BACKGROUND:

In early 2021, the 10-valent Pneumococcal conjugate vaccine (PCV10) was replaced with 13-valent (PCV13) by the federal directorate of immunization (FDI), Pakistan. We assessed the impact of a higher valent vaccine, PCV13, on the serotype distribution of nasopharyngeal carriage in rural Pakistan.

METHODS:

Children <2 years were randomly selected from two rural union councils of Matiari, Sindh in Pakistan between September-October,2022. Clinical, sociodemographic and vaccination histories were recorded. Nasopharyngeal swabs were collected and processed at Infectious Disease Research Laboratory, Aga Khan University, Karachi. Whole genome sequencing was performed on the culture positive isolates.

RESULTS:

Of the 200 children enrolled, pneumococcus was detected in 140(70 %) isolates. Majority of age-eligible children (60.1 %,110/183) received 3 PCV13 doses. PCV10 carriage declined from 13.2 %(78/590) in 2017/18 to 7.2 % (10/140) in 2022, additional PCV13 serotypes (3, 6A/6C and 19A) decreased from 18.5 %(109/590) to 11.4 %(16/140) while non-PCV13 serotypes increased from 68.3 %(403/590) to 81.4 %(114/140). There were 88.5 %(n = 124), 80.7 %(n = 113), 55.0 %(n = 77), and 46.0 %(n = 65) isolates predicted to be resistant to cotrimoxazole, penicillin(meningitis cut-off), tetracycline, and erythromycin respectively.

CONCLUSION:

Replacing PCV10 with PCV13 rapidly decreased prevalence of PCV13 carriage among vaccinated children in Matiari, Pakistan. Vaccine-driven selection pressure may have been responsible for the increase of non-PCV13 serotypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Portador Sano / Nasofaringe / Vacunas Neumococicas / Serogrupo Límite: Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Vaccine Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Portador Sano / Nasofaringe / Vacunas Neumococicas / Serogrupo Límite: Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Vaccine Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Países Bajos