Your browser doesn't support javascript.
loading
HLA-transgenic mouse models to study autoimmune central nervous system diseases.
Pressley, Kyle R; Schwegman, Lance; Montes De Oca Arena, Maria; Chase Huizar, Carol; Zamvil, Scott S; Forsthuber, Thomas G.
Afiliación
  • Pressley KR; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
  • Schwegman L; Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA.
  • Montes De Oca Arena M; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
  • Chase Huizar C; Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health at San Antonio, San Antonio, TX, USA.
  • Zamvil SS; Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
  • Forsthuber TG; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Autoimmunity ; 57(1): 2387414, 2024 Dec.
Article en En | MEDLINE | ID: mdl-39167553
ABSTRACT
It is known that certain human leukocyte antigen (HLA) genes are associated with autoimmune central nervous system (CNS) diseases, such as multiple sclerosis (MS), but their exact role in disease susceptibility and etiopathogenesis remains unclear. The best studied HLA-associated autoimmune CNS disease is MS, and thus will be the primary focus of this review. Other HLA-associated autoimmune CNS diseases, such as autoimmune encephalitis and neuromyelitis optica will be discussed. The lack of animal models to accurately capture the complex human autoimmune response remains a major challenge. HLA transgenic (tg) mice provide researchers with powerful tools to investigate the underlying mechanisms promoting susceptibility and progression of HLA-associated autoimmune CNS diseases, as well as for elucidating the myelin epitopes potentially targeted by T cells in autoimmune disease patients. We will discuss the potential role(s) of autoimmune disease-associated HLA alleles in autoimmune CNS diseases and highlight information provided by studies using HLA tg mice to investigate the underlying pathological mechanisms and opportunities to use these models for development of novel therapies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratones Transgénicos / Modelos Animales de Enfermedad / Antígenos HLA Límite: Animals / Humans Idioma: En Revista: Autoimmunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratones Transgénicos / Modelos Animales de Enfermedad / Antígenos HLA Límite: Animals / Humans Idioma: En Revista: Autoimmunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido