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Clinical and Biological Perspectives on Noncanonical Esophageal Squamous Cell Carcinoma in Rare Subtypes.
Pomenti, Sydney F; Flashner, Samuel P; Del Portillo, Armando; Nakagawa, Hiroshi; Gabre, Joel; Rustgi, Anil K; Katzka, David A.
Afiliación
  • Pomenti SF; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.
  • Flashner SP; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
  • Del Portillo A; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
  • Nakagawa H; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.
  • Gabre J; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.
  • Rustgi AK; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
  • Katzka DA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA.
Am J Gastroenterol ; 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39166765
ABSTRACT
Esophageal squamous cell carcinoma (ESCC) remains the most common malignancy of the esophagus worldwide. Environmental and lifestyle exposures such as alcohol and tobacco have been well defined in the pathogenesis of ESCC, acting in concert with cell intrinsic epigenomic, genomic and transcriptomic changes. However, a variety of nonenvironmental etiologies including Fanconi anemia, lichen planus, chronic mucocutaneous candidiasis, esophageal epidermoid metaplasia, epidermolysis bullosa, tylosis, esophageal atresia, and achalasia receive minimal attention despite a high risk of ESCC in these diseases. The goal of this review was to promote clinical recognition and suggest a diagnostic framework for earlier detection of ESCC in patients with these rare diseases. In all the discussed conditions, a change in symptoms should trigger a prompt endoscopic evaluation, and endoscopic surveillance programs with advanced imaging techniques and chromoendoscopy should be considered. Moreover, we leverage the convergence of these diseases on ESCC to identify common mechanisms underlying malignant transformation including aberrant proliferation, mucosal barrier dysfunction, increased inflammation, and genome instability. In this study, we summarize the clinical presentation, pathologic findings, potential screening strategies, and common mechanisms of malignant transformation associated with these rare diseases that drive ESCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos