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Treatment of Vedolizumab With Exclusive Enteral Nutrition in Adult Patients With Moderate to Severe Crohn's Disease (Crohn Exclusive Enteral Nutrition Study).
Wang, Jing; Tang, Zhishun; Li, Jiao; Yin, Anning; Xu, Yaqing; Zou, Liping; Ren, Haixia; Kang, Jian; Su, Juan; Zhou, Qian; Wang, Yang; Wang, Wei; Zhang, Jing; Wan, Huipeng; An, Ping.
Afiliación
  • Wang J; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Tang Z; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China.
  • Li J; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Yin A; Sports Rehabilitation, College of Sport Medicine, Wuhan Sports University, Wuhan, China.
  • Xu Y; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zou L; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China.
  • Ren H; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Kang J; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Su J; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhou Q; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
  • Wang Y; Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, China.
  • Wang W; The Clinical Skill Center, Teaching Office of the First School of Clinical Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhang J; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Wan H; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China.
  • An P; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China.
Clin Transl Gastroenterol ; 2024 Aug 21.
Article en En | MEDLINE | ID: mdl-39166756
ABSTRACT

INTRODUCTION:

Despite increasing studies confirming the efficacy of vedolizumab (VDZ) in Crohn's disease (CD), improving the responses to this biologic agent remains challenging in clinical practice. In this article, we investigated the efficacy of combined treatment of VDZ and 16-week exclusive enteral nutrition (EEN) in moderately to severely active CD.

METHODS:

From October 2020 to October 2023, 81 patients with moderately to severely active CD treated with VDZ from 2 inflammatory bowel disease centers were retrospectively selected. Forty-one patients received treatment of VDZ with concomitant 16-week EEN (VDZ + EEN cohort), and 40 patients received VDZ treatment alone (VDZ cohort). Clinical and biological outcomes were evaluated. Endoscopic response and mucosal healing were assessed by colonoscopy at weeks 16 and 52.

RESULTS:

There was no statistically significant difference between 2 groups at baseline for demographic and clinical characteristics. Compared with patients treated with VDZ alone, patients in the VDZ + EEN cohort achieved higher rates of clinical response (84.2% vs 40.0%), clinical remission (81.6% vs 30.0%), endoscopic response (91.4% vs 34.6%), including mucosal healing (85.7% vs 26.9%) at week 16. The superiority of VDZ + EEN treatment sustained in maintenance, with 76.7% (vs 33.3%) clinical response, 70.0% (vs 26.7%) clinical remission, 76.9% (vs 33.3%) endoscopic response, and 61.5% (vs 26.7%) mucosal healing at week 52. None of the patients experienced severe adverse events.

DISCUSSION:

VDZ with concomitant 16-week EEN might be an effective and optimized approach with solid efficacy in the induction and maintenance treatment of active CD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Gastroenterol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos