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Detection and analysis of parvovirus B19 among blood donors in a regional blood center in Eastern China.
Lu, Rong; Xie, Shuhong; Xu, Zihao; Liu, Zhen; Jiang, Jia; Tang, Longhai; Jin, Yiming; Fu, Xiaoyan.
Afiliación
  • Lu R; Department of Blood Screening Test, Suzhou Blood Center, Suzhou, China.
  • Xie S; Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, China.
  • Xu Z; Department of Blood Screening Test, Suzhou Blood Center, Suzhou, China.
  • Liu Z; Department of Blood Screening Test, Suzhou Blood Center, Suzhou, China.
  • Jiang J; Department of Blood Screening Test, Suzhou Blood Center, Suzhou, China.
  • Tang L; Transfusion Research Laboratory, Suzhou Blood Center, Suzhou, China.
  • Jin Y; Department of Blood Screening Test, Suzhou Blood Center, Suzhou, China.
  • Fu X; Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, China.
Heliyon ; 10(15): e35431, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39166038
ABSTRACT
Background and

objective:

The B19 virus is mainly transmitted through the respiratory tract; however, studies have shown that it can also be transmitted through blood transfusions or plasma products. This study investigated B19V antibodies, DNA, and gene typing in blood donors at a central blood station in China to evaluate the status of B19V infection. Materials and

methods:

A total of 7728 samples from Suzhou Blood Center were collected from July 2022 to April 2023. Samples were detected for the B19V DNA using real-time polymerase chain reaction. Furthermore, 893 selected samples were screened for the seroprevalence of B19V antibodies using enzyme-linked immunosorbent assay. The NS1-VP1u fragment of the B19V DNA-positive samples was amplified using nested PCR, and the sequences were determined. A B19V phylogenetic tree was constructed using neighborhood joint and maximum parsimony methods to discriminate genotypes using the NS1-VP1u sequences.

Results:

The percentages of IgG, IgM, and DNA were 19.4 %, 1.9 %, and 0.09 %, respectively. IgG positivity increased with age, and there was a significant difference among the blood groups. The IgG levels of repeat donors were greater than those of first-time donors. There were no apparent differences in the IgM levels in all the participants. Genotyping revealed that the B19 genotype was 1.

Conclusions:

The prevalence of B19V antibodies and DNA was lower in these areas than in rest of China, indicating that the risk of B19V transmission via transfusion may be relatively low. However, during transfusion, particular attention should be paid to the B19V-susceptible populations, especially those in high-risk groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido