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Rikkunshito improves anorexia through ghrelin- and orexin-dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats.
Yakabi, Koji; Yamaguchi, Naomi; Takayama, Kiyoshige; Hosomi, Eriko; Hori, Yutaro; Ro, Shoki; Ochiai, Mitsuko; Maezawa, Kosuke; Yakabi, Seiichi; Harada, Yumi; Fujitsuka, Naoki; Nagoshi, Sumiko.
Afiliación
  • Yakabi K; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Yamaguchi N; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Takayama K; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Hosomi E; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Hori Y; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Ro S; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Ochiai M; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Maezawa K; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Yakabi S; Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan.
  • Harada Y; Department of Gastroenterology, University of Tokyo Hospital, Tokyo, Japan.
  • Fujitsuka N; TSUMURA Kampo Research Laboratories, TSUMURA ＆ CO., Ibaraki, Japan.
  • Nagoshi S; TSUMURA Kampo Research Laboratories, TSUMURA ＆ CO., Ibaraki, Japan.
Neurogastroenterol Motil ; 36(11): e14900, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39164871
ABSTRACT

BACKGROUND:

Rikkunshito (RKT), a traditional Japanese medicine, can relieve epigastric discomfort and anorexia in patients with functional dyspepsia. RKT enhances the orexigenic hormone, ghrelin. Ghrelin regulates food motivation by stimulating the appetite control center in the hypothalamus and the brain mesolimbic dopaminergic pathway (MDPW). However, the effect of RKT on MDPW remains unclear. Here, we aimed to investigate the central neural mechanisms underlying the orexigenic effects of RKT, focusing on the MDPW.

METHODS:

We examined the effects of RKT on food intake and neuronal c-Fos expression in restraint stress- and cholecystokinin octapeptide-induced anorexia in male rats. KEY

RESULTS:

RKT treatment significantly restored stress- and cholecystokinin octapeptide-induced decreased food intake. RKT increased c-Fos expression in the ventral tegmental area (VTA), especially in tyrosine hydroxylase-immunoreactive neurons, and nucleus accumbens (NAc). The effects of RKT were suppressed by the ghrelin receptor antagonist [D-Lys3]-GHRP-6. RKT increased the number of c-Fos/orexin-double-positive neurons in the lateral hypothalamus (LH), which project to the VTA. The orexin receptor antagonist, SB334867, suppressed RKT-induced increase in food intake and c-Fos expression in the LH, VTA, and NAc. RKT increased c-Fos expression in the arcuate nucleus and nucleus of the solitary tract of the medulla, which was inhibited by [D-Lys3]-GHRP-6. CONCLUSIONS & INFERENCES RKT may restore appetite in subjects with anorexia through ghrelin- and orexin-dependent activation of neurons regulating the brain appetite control network, including the hypothalamus and MDPW.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Anorexia / Ghrelina / Orexinas / Hipotálamo Límite: Animals Idioma: En Revista: Neurogastroenterol Motil Asunto de la revista: GASTROENTEROLOGIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Anorexia / Ghrelina / Orexinas / Hipotálamo Límite: Animals Idioma: En Revista: Neurogastroenterol Motil Asunto de la revista: GASTROENTEROLOGIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido