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Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection.
Pischke, S; Kjasimov, A; Skripuletz, T; Casar, C; Bannasch, J; Mader, M; Huber, S; Konen, F; Wolski, A; Horvatits, T; Gingele, S; Peine, S; Hiller, J; Seeliger, T; Thayssen, G; Lütgehetmann, M; Schulze Zur Wiesch, J; Golsari, A; Gelderblom, M.
Afiliación
  • Pischke S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany. s.pischke@uke.de.
  • Kjasimov A; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany. s.pischke@uke.de.
  • Skripuletz T; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Casar C; Department of Neurology, Hannover Medical School, Hannover, Germany.
  • Bannasch J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Mader M; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Huber S; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany.
  • Konen F; Institute for Microbiology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Wolski A; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Horvatits T; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Gingele S; Department of Neurology, Hannover Medical School, Hannover, Germany.
  • Peine S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Hiller J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
  • Seeliger T; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, Germany.
  • Thayssen G; Department of Neurology, Hannover Medical School, Hannover, Germany.
  • Lütgehetmann M; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schulze Zur Wiesch J; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Golsari A; Department of Neurology, Hannover Medical School, Hannover, Germany.
  • Gelderblom M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sci Rep ; 14(1): 19244, 2024 08 20.
Article en En | MEDLINE | ID: mdl-39164378
ABSTRACT
Guillain-Barré syndrome and neuralgic amyotrophy have been associated with hepatitis E virus (HEV) genotype 3 infections, while myasthenia gravis (MG) has been associated with HEV genotype 4 infections. However, whether chronic inflammatory demyelinating polyneuropathy (CIDP) is associated with HEV infections has not been conclusively clarified yet. 102 CIDP patients, 102 age- and sex-matched blood donors, 61 peripheral neuropathy patients (non-CIDP patients), and 26 MG patients were tested for HEV and anti-HEV IgM and IgG. Sixty-five of the 102 (64%) CIDP patients tested positive for anti-HEV IgG and one (1%) for anti-HEV IgM. No other patient tested positive for ati-HEV IgM. In the subgroup of CIDP patients with initial diagnosis (without previous IVIG treatment), 30/54 (56%) tested positive for anti-HEV IgG. Anti-HEV rates were significantly lower in blood donors (28%), non-CIDP peripheral neuropathy patients (20%), and MG patients (12%). No subject tested positive for HEV viremia. CSF tested negative for in 61 CIDP patients (54 patients with primary diagnosis). The development of CIDP but not non-CIDP polyneuropathy may be triggered by HEV exposure in an HEV genotype 3 endemic region. The increased anti-HEV seroprevalence in CIDP patients is not a consequence of IVIG therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Inmunoglobulina M / Virus de la Hepatitis E / Hepatitis E / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Inmunoglobulina M / Virus de la Hepatitis E / Hepatitis E / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido