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Non-human primate model of long-COVID identifies immune associates of hyperglycemia.
Palmer, Clovis S; Perdios, Chrysostomos; Abdel-Mohsen, Mohamed; Mudd, Joseph; Datta, Prasun K; Maness, Nicholas J; Lehmicke, Gabrielle; Golden, Nadia; Hellmers, Linh; Coyne, Carol; Moore Green, Kristyn; Midkiff, Cecily; Williams, Kelsey; Tiburcio, Rafael; Fahlberg, Marissa; Boykin, Kyndal; Kenway, Carys; Russell-Lodrigue, Kasi; Birnbaum, Angela; Bohm, Rudolf; Blair, Robert; Dufour, Jason P; Fischer, Tracy; Saied, Ahmad A; Rappaport, Jay.
Afiliación
  • Palmer CS; Tulane National Primate Research Center, Covington, LA, USA. cpalmer3@tulane.edu.
  • Perdios C; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. cpalmer3@tulane.edu.
  • Abdel-Mohsen M; Tulane National Primate Research Center, Covington, LA, USA.
  • Mudd J; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Datta PK; The Wistar Institute, Philadelphia, PA, USA.
  • Maness NJ; Tulane National Primate Research Center, Covington, LA, USA.
  • Lehmicke G; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Golden N; Tulane National Primate Research Center, Covington, LA, USA.
  • Hellmers L; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Coyne C; Tulane National Primate Research Center, Covington, LA, USA.
  • Moore Green K; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Midkiff C; Tulane National Primate Research Center, Covington, LA, USA.
  • Williams K; Tulane National Primate Research Center, Covington, LA, USA.
  • Tiburcio R; Tulane National Primate Research Center, Covington, LA, USA.
  • Fahlberg M; Tulane National Primate Research Center, Covington, LA, USA.
  • Boykin K; Tulane National Primate Research Center, Covington, LA, USA.
  • Kenway C; Tulane National Primate Research Center, Covington, LA, USA.
  • Russell-Lodrigue K; Tulane National Primate Research Center, Covington, LA, USA.
  • Birnbaum A; Division of Experimental Medicine, Department of Medicine, University of San Francisco, CA, USA.
  • Bohm R; Tulane National Primate Research Center, Covington, LA, USA.
  • Blair R; Tulane National Primate Research Center, Covington, LA, USA.
  • Dufour JP; Tulane National Primate Research Center, Covington, LA, USA.
  • Fischer T; Tulane National Primate Research Center, Covington, LA, USA.
  • Saied AA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
  • Rappaport J; Tulane National Primate Research Center, Covington, LA, USA.
Nat Commun ; 15(1): 6664, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39164284
ABSTRACT
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys. Using this model, we identify a dysregulated blood chemokine signature during acute COVID-19 that correlates with elevated and persistent hyperglycemia four months post-infection. Hyperglycemia also correlates with liver glycogen levels, but there is no evidence of substantial long-term SARS-CoV-2 replication in the liver and pancreas. Finally, we report a favorable glycemic effect of the SARS-CoV-2 mRNA vaccine, administered on day 4 post-infection. Together, these data suggest that the African green monkey model exhibits important similarities to humans and can be utilized to assess therapeutic candidates to combat COVID-related metabolic defects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / SARS-CoV-2 / COVID-19 / Hiperglucemia / Hígado Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / SARS-CoV-2 / COVID-19 / Hiperglucemia / Hígado Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido