Fracture-related infection blood-based biomarkers: Diagnostic strategies.

Natoli, Roman M; Malek, Sarah

Natoli, Roman M; Malek, Sarah.

Afiliación

Natoli RM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: rnatoli@iuhealth.org.
Malek S; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.

Injury ; : 111823, 2024 Aug 13.

Article en En | MEDLINE | ID: mdl-39164161

ABSTRACT

ABSTRACT

Fracture-related infections are significant postoperative complications that carry substantial patient burden and additional healthcare costs. Despite their impact on outcome, early diagnosis of these infections remains challenging due to current available tests lacking acceptable diagnostic parameters. This review compiles existing information on blood-based biomarkers that have been evaluated as early diagnostic tools and highlights the challenges in their reliability. To begin to overcome these challenges new avenues of biomarker discovery utilizing "omics" technologies and novel analytical methods are being investigated in recent years. It appears that, despite their complexity, these newer approaches may be the future in biomarker discovery for fracture-related infection diagnosis.

Palabras clave

Biomarker; Fracture; Infection

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Injury Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

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