Clinical Impact of Microbiome Characteristics in Treatment-Naïve Extranodal NK/T-Cell Lymphoma Patients.

Yoon, Sang Eun; Kang, Woorim; Cho, Junhun; Chalita, Mauricio; Lee, Je Hee; Hyun, Dong-Wook; Kim, Hyun; Kim, Seok Jin; Kim, Won Seog

Yoon, Sang Eun; Kang, Woorim; Cho, Junhun; Chalita, Mauricio; Lee, Je Hee; Hyun, Dong-Wook; Kim, Hyun; Kim, Seok Jin; Kim, Won Seog.

Afiliación

Yoon SE; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kang W; CJ Bioscience Inc., Seoul, Korea.
Cho J; Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Chalita M; CJ Bioscience Inc., Seoul, Korea.
Lee JH; CJ Bioscience Inc., Seoul, Korea.
Hyun DW; CJ Bioscience Inc., Seoul, Korea.
Kim H; CJ Bioscience Inc., Seoul, Korea.
Kim SJ; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim WS; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Cancer Res Treat ; 2024 Aug 16.

Article en En | MEDLINE | ID: mdl-39164084

ABSTRACT

ABSTRACT

Purpose:

Extranodal NK/T-cell lymphoma (ENKTL) predominantly manifests in East Asia and Latin America. Despite shared intrinsic factors, such as ethnic and genetic backgrounds, the progression of ENKTL can be influenced by extrinsic factors related to changing lifestyle patterns. Materials and

Methods:

This study collected stool samples from newly diagnosed (ND)-ENKTL patients (n=40) and conducted whole genome shotgun sequencing.

Results:

ND-ENKTL revealed reduced alpha diversity in ND-ENKTL compared to healthy controls (HCs) (p=0.008), with Enterobacteriaceae abundance significantly contributing to the beta diversity difference between ENKTL and HCs (p<0.001). Functional analysis indicated upregulated aerobic metabolism and degradation of aromatic compounds in ND-ENKTL. Enterobacteriaceae were associated not only with clinical data explaining disease status (serum CRP, stage, prognosis index of natural killer cell lymphoma (PINK), and PINK-E) but also with clinical outcomes (early relapse and short progression-free survival). The relative abundance of Enterobacteriaceae at the family level was similar between ENKTL and diffuse large B-cell lymphoma (DLBCL) (p=0.140). However, the ENKTL exhibited a higher abundance of Escherichia, in contrast to the prevalence of Enterobacter and Citrobacter in DLBCL. Linear regression analysis demonstrated a significant association between Escherichia abundance and PD-L1 levels in tissue samples (p=0.025), whereas no correlation with PD-L1 was observed for Enterobacteriaceae at the family level (p=0.571).

Conclusion:

ND-ENKTL exhibited an abundance of Enterobacteriaceae and a dominant presence of Escherichia. These microbial characteristics correlated with disease status, treatment outcomes, and PD-L1 expression, suggesting the potential of the ENKTL microbiome as a biomarker and cause of lymphomagenesis, which warrants further exploration.

Palabras clave

Abundance; Diffuse large B-cell lymphoma; Diversity; Extranodal NK/T-cell lymphoma; Microbiome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancer Res Treat Año: 2024 Tipo del documento: Article Pais de publicación: