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COVID-19's Radiologic, Functional, and Serologic Consequences at 6-Month and 18-Month Follow-up: A Prospective Cohort Study.
Kim, Cherry; Seok, Hyeri; Kim, Jooyun; Park, Dae Won; van Assen, Marly; De Cecco, Carlo N; Choi, Hangseok; Kim, Chohee; Hwang, Sung Ho; Yong, Hwan Seok; Oh, Yu-Whan; Choi, Won Suk.
Afiliación
  • Kim C; Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • Seok H; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • Kim J; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • Park DW; Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • van Assen M; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • De Cecco CN; Translational Laboratory for Cardiothoracic Imaging and Artificial Intelligence, Emory University School of Medicine, Atlanta, GA, USA.
  • Choi H; Translational Laboratory for Cardiothoracic Imaging and Artificial Intelligence, Emory University School of Medicine, Atlanta, GA, USA.
  • Kim C; Division of Cardiothoracic Imaging, Department of Radiology, Emory University, Atlanta, GA, USA.
  • Hwang SH; Medical Science Research Center, Korea University College of Medicine, Seoul, Korea.
  • Yong HS; Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • Oh YW; Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
  • Choi WS; Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
J Korean Med Sci ; 39(32): e228, 2024 Aug 19.
Article en En | MEDLINE | ID: mdl-39164053
ABSTRACT

BACKGROUND:

We evaluated the radiologic, pulmonary functional, and antibody statuses of coronavirus disease 2019 (COVID-19) patients 6 and 18 months after discharge, comparing changes in status and focusing on risk factors for residual computed tomography (CT) abnormalities.

METHODS:

This prospective cohort study was conducted on COVID-19 patients discharged between April 2020 and January 2021. Chest CT, pulmonary function testing (PFT), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) measurements were performed 6 and 18 months after discharge. We evaluated factors associated with residual CT abnormalities and the correlation between lesion volume in CT (lesionvolume), PFT, and IgG levels.

RESULTS:

This study included 68 and 42 participants evaluated 6 and 18 months, respectively, after hospitalizations for COVID-19. CT abnormalities were noted in 22 participants (32.4%) at 6 months and 13 participants (31.0%) at 18 months. Lesionvolume was significantly lower at 18 months than 6 months (P < 0.001). Patients with CT abnormalities at 6 months showed lower forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC), and patients with CT abnormalities at 18 months exhibited lower FVC. FVC significantly improved between 6 and 18 months of follow-up (all P < 0.0001). SARS-CoV-2 IgG levels were significantly higher in patients with CT abnormalities at 6 and 18 months (P < 0.001). At 18-month follow-up assessments, age was associated with CT abnormalities (odds ratio, 1.17; 95% confidence interval, 1.03-1.32; P = 0.01), and lesionvolume showed a positive correlation with IgG level (r = 0.643, P < 0.001).

CONCLUSION:

At 18-month follow-up assessments, 31.0% of participants exhibited residual CT abnormalities. Age and higher SARS-CoV-2 IgG levels were significant predictors, and FVC was related to abnormal CT findings at 18 months. Lesionvolume and FVC improved between 6 and 18 months. TRIAL REGISTRATION Clinical Research Information Service Identifier KCT0008573.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Función Respiratoria / Inmunoglobulina G / Tomografía Computarizada por Rayos X / SARS-CoV-2 / COVID-19 / Pulmón Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Función Respiratoria / Inmunoglobulina G / Tomografía Computarizada por Rayos X / SARS-CoV-2 / COVID-19 / Pulmón Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: