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Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method.
Zhang, Wen; Hu, Xinyue; Jiang, Fei; Li, Yirui; Chen, Wenhao; Zhou, Ting.
Afiliación
  • Zhang W; School of Food and Engineering, Shaanxi University of Science and Technology, Xi'an, China.
  • Hu X; School of Food and Engineering, Shaanxi University of Science and Technology, Xi'an, China.
  • Jiang F; Zhejiang Jiuzhou Pharmaceutical Co, Taizhou, China.
  • Li Y; School of Food and Engineering, Shaanxi University of Science and Technology, Xi'an, China.
  • Chen W; Sichuan Provincial Key Laboratory of Solid State Fermentation Resource Utilization, Yibin University, Sichuan, China.
  • Zhou T; China Certification & Inspection Group Shaanxi Co, LTD, Xi'an, China.
J Biomater Sci Polym Ed ; : 1-23, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39163367
ABSTRACT
Conventional wound dressings used in trauma treatment have a single function and insufficient adaptability to the wound environment, making it difficult to meet the complex demands of the healing process. Stimuli-responsive hydrogels can respond specifically to the particular environment of the wound area and realize on-demand responsive release by loading active substances, which can effectively promote wound healing. In this paper, BC/PAA-pH responsive hydrogels (BPPRHs) were prepared by graft copolymerization of acrylic acid (AA) to the end of the molecular chain of bacterial cellulose (BC) network structure. Antibacterial pH-responsive 'smart' dressings were prepared by loading curcumin (Cur) onto the hydrogels. Surface morphology, chemical groups, crystallinity, rheological, and mechanical properties of BPPRHs were analyzed by different characterization methods. The drug release behavior under different physiological conditions and bacteriostatic properties of BPPRH-Cur dressings were also investigated. The results of structural characterization and performance studies show that the hydrogel has a three-dimensional mesh structure and can respond to wound pH in a 'smart' drug release capacity. The drug release behavior of the BPPRH-Cur dressings under different environmental conditions conformed to the logistic and Weibull kinetic models. BPPRH-Cur displayed good antimicrobial activity against common pathogens of wound infections such as E. coli, S. aureus, and P. aeruginosa by destroying the cell membrane and lysing the bacterial cells. This study lays the foundation for the development of new pharmaceutical dressings with positive health, economic and social benefits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomater Sci Polym Ed Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomater Sci Polym Ed Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido