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Small molecule communication of Legionella: the ins and outs of autoinducer and nitric oxide signaling.
Michaelis, Sarah; Gomez-Valero, Laura; Chen, Tong; Schmid, Camille; Buchrieser, Carmen; Hilbi, Hubert.
Afiliación
  • Michaelis S; Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
  • Gomez-Valero L; Institut Pasteur, Université de Paris, Unité Biologie des Bactéries Intracellulaires, Paris, France.
  • Chen T; Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
  • Schmid C; Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
  • Buchrieser C; Institut Pasteur, Université de Paris, Unité Biologie des Bactéries Intracellulaires, Paris, France.
  • Hilbi H; Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland.
Microbiol Mol Biol Rev ; : e0009723, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39162424
ABSTRACT
SUMMARYLegionella pneumophila is a Gram-negative environmental bacterium, which survives in planktonic form, colonizes biofilms, and infects protozoa. Upon inhalation of Legionella-contaminated aerosols, the opportunistic pathogen replicates within and destroys alveolar macrophages, thereby causing a severe pneumonia termed Legionnaires' disease. Gram-negative bacteria employ low molecular weight organic compounds as well as the inorganic gas nitric oxide (NO) for cell-cell communication. L. pneumophila produces, secretes, and detects the α-hydroxyketone compound Legionella autoinducer-1 (LAI-1, 3-hydroxypentadecane-4-one). LAI-1 is secreted by L. pneumophila in outer membrane vesicles and not only promotes communication among bacteria but also triggers responses from eukaryotic cells. L. pneumophila detects NO through three different receptors, and signaling through the volatile molecule translates into fluctuations of the intracellular second messenger cyclic-di-guanylate monophosphate. The LAI-1 and NO signaling pathways are linked via the pleiotropic transcription factor LvbR. In this review, we summarize current knowledge about inter-bacterial and inter-kingdom signaling through LAI-1 and NO by Legionella species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microbiol Mol Biol Rev Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Microbiol Mol Biol Rev Asunto de la revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos