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Notch Signaling in Central Nervous System: From Cellular Development to Multiple Sclerosis Disease.
Askari, Hamid; Rabiei, Fatemeh; Biagini, Giuseppe; Yahyazadeh, Masoomeh; Ghasemi-Kasman, Maryam.
Afiliación
  • Askari H; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
  • Rabiei F; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
  • Biagini G; Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Yahyazadeh M; Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
  • Ghasemi-Kasman M; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Curr Neuropharmacol ; 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39162293
ABSTRACT
INTRODUCTION/

OBJECTIVE:

Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate roles of Notch signaling could pave the way for targeted interventions to mitigate MS progression.

METHODS:

A comprehensive literature review was conducted using databases such as PubMed, Web of Science, and Scopus. Keywords such as "Notch signaling," "neuroglial interactions," and "MS" were used. The selection criteria included relevance to neuroglial interactions, peer-reviewed publications, and studies involving animal models of MS.

RESULTS:

This review highlights the diverse functions of Notch signaling in CNS development, including its regulation of neural stem cell differentiation into neurons, astrocytes, and oligodendrocytes. In the context of MS, Notch signaling has emerged as a promising therapeutic target, exhibiting positive impacts on neuroprotection and remyelination. However, its intricate nature within the CNS necessitates precise modulation for therapeutic efficacy.

CONCLUSION:

This study provides a comprehensive overview of the potential therapeutic role of Notch signaling in MS. The findings underscore the significance of Notch modulation for neuroprotection and remyelination, emphasizing the need for precision in therapeutic interventions. Further research is imperative to elucidate the specific underlying mechanisms involved, which will provide a foundation for targeted therapeutic strategies for the management of MS and related neurodegenerative disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Neuropharmacol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Neuropharmacol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Emiratos Árabes Unidos