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Genetic polymorphisms in external apical root resorption and orthodontic tooth movements: A systematic review.
Andrade, Ana Luiza Cabral de Ávila; Pinto, Yasmin Dias de Almeida; Maia, Bernardo Emerenciano Barros; Corrêa, Joice Dias; Miranda, Diogo de Azevedo; Manzi, Flávio Ricardo; Lima, Izabella Lucas de Abreu.
Afiliación
  • Andrade ALCÁ; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
  • Pinto YDA; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
  • Maia BEB; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
  • Corrêa JD; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
  • Miranda DA; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
  • Manzi FR; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
  • Lima ILA; Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
Korean J Orthod ; 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39162020
ABSTRACT

Objective:

External apical root resorption (EARR) is characterized by permanent loss of dental structure at the root apex. This study aimed to systematically review gene polymorphisms associated with EARR in orthodontic patients.

Methods:

Electronic database searches were performed across several databases.

Results:

This systematic review included 21 studies. Outcome measures were based on tooth dimensions observed on radiographs obtained before and after treatment. Polymorphisms in the following genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism

analysis:

purinergic-receptor-P2X, ligand-gated ion channel 7 (P2RX7), caspase-1/interleukin-converting enzyme (CASP1/ICE), caspase-5 (CASP5), IL-1beta (IL1B), IL-1alpha (IL1A), interleukin-1 receptor antagonist gene (IL1RN), tissue non-specific alkaline phosphatase (TNSALP), tumor necrosis factor-alpha (TNFα), tumor necrosis factor receptor superfamily gene member 11a (TNFRSF11A), secreted phosphoprotein 1 (SPP1), tumor necrosis factor receptor superfamily gene member 11b (TNFRSF11B), interleukin 17A (IL17), interleukin 6 (IL6), receptor activator of nuclear factor-kappa B (RANK), osteoprotegerin (OPG), stromal antigen 2 (STAG2), vitamin D receptor (VDR), cytochrome P450 family 24 subfamily A member 1 (CYP24A1), cytochrome P450 family 27 subfamily B (CYP27B1), group-specific component (GC), and interleukin-1 receptor-associated kinases 1 (IRAK1).

Conclusions:

Almost all studies suggested that IL1 gene is associated with EARR. Additionally, P2RX7 may be an important factor contributing to the etiopathogenesis of EARR. TNFRSF11A, SPP1, IL1RN, IL6, TNFRSF11B, STAG2, VDR, IRAK1, IL-17, CASP1/ICE and CASP5 have been identified in isolated studies. Further observational studies are needed to better explain the association between these genes and EARR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Korean J Orthod Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Korean J Orthod Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: